Results 121 to 130 of about 526,290 (218)

SatRNA-mediated exacerbation of disease symptoms in plants reduces virus transmission potential by aphids. [PDF]

BMC Plant Biol
Wrzesińska-Krupa B, Frąckowiak P, Budziszewska M, Strażyński P, Obrępalska-Stęplowska A.   +4 more
europepmc   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Environmental considerations in hepatitis E virus transmission: Is there a missing link? [PDF]

World J Hepatol
Campbell R, Russell C, Izopet J, Nassim K, Sonderup M, Pischke S, Wallace SJ, Madden RG.   +7 more
europepmc   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

ENSO Impact on Global Chikungunya Virus Transmission, 2008-2024: A Multi-Country Distributed-Lag Time-Series Analysis. [PDF]

Viruses
Shan SH, Chen LT, Xie WQ, Lv CL, Jiang D, Ding FY, Dong G, Fang LQ.   +7 more
europepmc   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Nosocomial Dengue by Mucocutaneous Transmission

Emerging Infectious Diseases, 2005
Lin H. Chen, Mary E. Wilson
doaj   +1 more source

The impact of viral and host factors on the influenza A virus transmission bottleneck. [PDF]

PLoS Pathog
Krupinsky KC, Bendall EE, Zhu Y, Stockwell MS, Nguyen HQ, Meece JK, Maldonado Y, Ellingson KD, Lutrick K, Asturias EJ, Rao S, Bowman NM, Rolfes M, Biddle JE, Mellis A, Schmitz JE, Chappell JD, Halasa NB, Fitzsimmons WJ, Martin ET, Grijalva CG, Talbot HK, Lauring AS.   +22 more
europepmc   +1 more source

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Oropouche virus: transmission, epidemiology, genetic diversity, and public health implications. [PDF]

EClinicalMedicine
Subissi L, Otieno JR, Ruis C, Rabe I, Agrawal A, Abu-Raddad LJ, Azhar EI, Beer M, Bezerra H, Caly L, Chand M, Companioni A, de Oliveira T, Dietrich I, Drosten C, Duran P, Faria NR, Fowotade A, Gresh L, Huang B, Kindrachuk J, Koopmans MPG, Korber B, Leo YS, Mbala-Kingebeni P, McMenamin M, Melhem NM, Munster VJ, Nunes BTD, Oude Munnink BB, Naveca FG, Peiris M, Palacios G, Resende P, Rodriguez A, Saha S, Suzuki T, Vicari A, von Gottberg A, Yadav P, Mendez-Rico J, Van Kerkhove MD, Rojas DP.   +42 more
europepmc   +1 more source