Results 1 to 10 of about 258,340 (266)

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence [PDF]

, 2004
Discrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and ...
Evans, David J, Simmonds, Peter, Tuplin, Andrew, Tuplin, A, Evans, DJ, Simmonds, P   +5 more
core   +1 more source

Widespread interspecific phylogenetic tree incongruence between mosquito-borne and insect-specific flaviviruses at hotspots originally identified in Zika virus

, 2022
Intraspecies (homologous) phylogenetic incongruence, or 'tree conflict' between different loci within the same genome of mosquito-borne flaviviruses (MBFV), was first identified in dengue virus (DENV) and subsequently in Japanese encephalitis virus (JEV),
Gaunt, Bill, Gould, Ernest A., de Lamballerie, Xavier, Kuno, Goro,, de Lamballerie, Xavier,, Gould, Ernest A.,, Gould, Ernest A, Gaunt, Michael W.,, Pettersson, John, Gaunt, Michael W., Pettersson, John,, Gaunt, Michael W, Kuno, Goro, Pettersson, John H-O, Gaunt, Bill,   +14 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Antigenic drift in H5N1 avian influenza virus in poultry is driven by mutations in major antigenic sites of the hemagglutinin molecule analogous to those for human influenza virus [PDF]

, 2011
H5N1 highly pathogenic avian influenza virus has been endemic in poultry in Egypt since 2008, notwithstanding the implementation of mass vaccination and culling of infected birds.
Arafa, Abdel, Temperton, Nigel J., Giovanni Cattoli, Alessandra Buratin, Mona Meherez Aly, Adelaide Milani, Cattoli, Giovanni, Milani, Adelaide, Zecchin, Bianca, Ilaria Capua, Capua, Ilaria, Eleonora Molesti, Bianca Zecchin, Abdel Arafa, Buratin, Alessandra, Aly, Mona Meherez, Temperton, Nigel, Meherez Aly, Mona, Nigel Temperton, Molesti, Eleonora   +19 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection

, 2006
Cellular immune responses are an important correlate of hepatitis C virus (HCV) infection outcome. These responses are governed by the host's human leukocyte antigen (HLA) type, and HLA-restricted viral escape mutants are a critical aspect of this host ...
Cheng, Wendy, Battegay, Manuel, E. Freitas, Weber, R., Furrer, H., Jeffrey, G., James, Ian, Park, Lawrence P, Swiss HIV Cohort Study,, G. Jeffrey, Battegay, M., Jeffrey, Gary, Herrmann, S., James, I., Weber, R., Battegay, M., Chapman, R., S. Herrmann, Furrer, Hansjakob, Telenti, Amalio, Freitas, E., Telenti, A., Lucas, M., M. Lucas, null null, I. James, Weber, Rainer, Telenti, A., Lucas, M., Freitas, Elizabeth, H. Furrer, Cheng, W., Jeffrey, G., Gaudieri, S., S. A. Mallal, Park, P., Freitas, E., Cheng, W., K. Pfafferott, Pfafferott, K., S. Gaudieri, R. Weber, Naidoo, Kiloshni, A. Rauch, Pfafferott, K., Mallal, Simon A, L. P. Park, Rauch, A., Chapman, R., A. Telenti, Pfafferott, Katja, R. Chapman, Lucas, Michaela, M. Battegay, Park, L.P., Naidoo, K., Herrmann, Susan, K. Naidoo, Furrer, H., Rauch, Andri, Park, L. P., W. Cheng, Herrmann, S., Naidoo, K., Chapman, Russell, Rauch, A., Mallal, S.A., Gaudieri, S., Mallal, S. A., James, I., Gaudieri, Silvana   +70 more
core   +1 more source

Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection [PDF]

, 2007
Background. CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C.
Paul Klenerman, GRÜNER N, Thimme, R., J. Tilman Gerlach, Weber, Jonathan N., Ulsenheimer, Axel, Helmut M. Diepolder, PFAFFEROT K, Semmo, N, Scriba, Thomas J, Silvana Gaudieri, Hans Nitschko, Grüner Norbert, SANTANTONIO, TERESA ANTONIA, Haberstroh, Anita, Diepolder Helmut M., Pfafferot, Katja, Jung, Maria-Christina, Rauch, A, Norbert Grüner, Andri Rauch, Scriba, T.J., Obermeier, M., Diepolder, HM, Pape Gerd R., Jonathan N Weber, Gaudieri Silvana, Malte H. J. Heeg, OBERMEIER M, Anita Haberstroh, SCHRAUT W, Jung, M-C, Gerd R Pape, Michaela Lucas, FIDLER S, RAUCH A, DAY C, Phillips, Rodney, Malte H.J. Heeg, Gaudieri, S., Maria-Christina Jung, Thimme Robert, Pape, Gerd R., Obermeier, Martin, Obermeier Martin, Day Cheryl, Obermeier, M, Rodney Phillips, Klenerman Paul, Heeg, MH, Martin Obermeier, Haberstroh, A., Day, C., Klenerman, Paul, Grüner, Norbert, Zachoval, R., Thimme, Robert, Baumert, Thomas F., Phillips, R., Gerlach, JT, Haberstroh Anita, Gerlach, J Tilman, Klenerman, P, Santantonio, T., ZACHOVAL R, Ulsenheimer, A., Nitschko, Hans, Lucas, Michaela, Nasser Semmo, Zachoval Reinhart, KLENERMAN P, Weber, J.N., Baumert Thomas F., Bowyer, S., Fidler, Sarah, Phillips Rodney, Haberstroh, A, Heeg Malte H.J., ULSENHEIMER A, Thomas F. Baumert, Baumert, TF, Diepolder, Helmut M, Axel Ulsenheimer, Thomas F Baumert, Gruener, N, Pfafferot, K, Pape, GR, Helmut M Diepolder, BAUMERT TF, Winfried Schraut, Jung, M.C., Zachoval, R, Gerlach, J.T., Thimme, R, Phillips, R, LUCAS M, Semmo, N., Heeg, Malte H. J., Semmo Nasser, HEEG MH, Gerlach J. Tilman, Nitschko Hans, HABERSTROH A, Santantonio Teresa, Robert Thimme, Grüner, N., Santantonio, T, Schraut Winfried, Klenerman, P., Pape, Gerd R, J. Tilman, Santantonio, Teresa, Scriba, Thomas J., Nitschko, H., Jung, MC, Jonathan N. Weber, Reinhart Zachoval, Scriba, TJ, NITSCHKO H, Lucas, M., Katja Pfafferot, Jung Maria-Christina, Fidler, S., Heeg, M., Schraut, Winfried, Malte H J Heeg, J Tilman Gerlach, Pfafferot Katja, Weber Jonathan N., Diepolder, H.M., Baumert, T.F., Gaudieri, S, Cheryl Day, GAUDIERI S, PAPE GR, Lucas, M, Fidler Sarah, WEBER JN, DIEPOLDER HM, Weber, Jonathan N, Schraut, W., Day, C, Ulsenheimer, A, Gerlach, J. Tilman, SEMMO N, Thomas J Scriba, Ulsenheimer Axel, Day, Cheryl, Lucas Michaela, PHILLIPS R, Diepolder, Helmut M., Pfafferott, K., Heeg, MHJ, Fidler, S, Rauch, A., Thomas J. Scriba, GERLACH JT, Gruner, N, Nitschko, H, Heeg, Malte H J, Gerd R. Pape, Sarah Fidler, Rauch Andri, Rauch, Andri, Baumert, Thomas F, Scriba Thomas J., Pape, G.R., Schraut, W, THIMME R, Semmo, Nasser, Weber, JN, JUNG MC, Teresa Santantonio, Gaudieri, Silvana, Zachoval, Reinhart, SCRIBA TJ   +175 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source