Results 31 to 40 of about 3,988,806 (312)

Dating the Emergence of Human Endemic Coronaviruses

Viruses, 2022
Four endemic coronaviruses infect humans and cause mild symptoms. Because previous analyses were based on a limited number of sequences and did not control for effects that affect molecular dating, we re-assessed the timing of endemic coronavirus ...
Diego Forni, Rachele Cagliani, Uberto Pozzoli, Alessandra Mozzi, Federica Arrigoni, Luca De Gioia, Mario Clerici, Manuela Sironi   +7 more
doaj   +1 more source

Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection [PDF]

, 2006
Cellular immune responses are an important correlate of hepatitis C virus (HCV) infection outcome. These responses are governed by the host's human leukocyte antigen (HLA) type, and HLA-restricted viral escape mutants are a critical aspect of this host ...
Cheng, Wendy, Battegay, Manuel, E. Freitas, Jeffrey, G., James, Ian, Park, Lawrence P, Swiss HIV Cohort Study,, G. Jeffrey, Battegay, M., Jeffrey, Gary, Weber, R., Chapman, R., S. Herrmann, Furrer, Hansjakob, Telenti, Amalio, Telenti, A., Lucas, M., M. Lucas, null null, I. James, Weber, Rainer, Freitas, Elizabeth, H. Furrer, Gaudieri, S., S. A. Mallal, Park, P., Freitas, E., Cheng, W., K. Pfafferott, S. Gaudieri, R. Weber, Naidoo, Kiloshni, A. Rauch, Pfafferott, K., Mallal, Simon A, L. P. Park, Rauch, A., A. Telenti, Pfafferott, Katja, R. Chapman, Lucas, Michaela, M. Battegay, Park, L.P., Herrmann, Susan, K. Naidoo, Furrer, H., Rauch, Andri, W. Cheng, Herrmann, S., Naidoo, K., Chapman, Russell, Mallal, S.A., James, I., Gaudieri, Silvana, Park, Lawrence P., Mallal, S. A., Mallal, Simon A., Park, L. P.   +57 more
core   +1 more source

Recombination and Positive Selection Differentially Shaped the Diversity of Betacoronavirus Subgenera

Viruses, 2020
The Betacoronavirus genus of mammal-infecting viruses includes three subgenera (Sarbecovirus, Embecovirus, and Merbecovirus), in which most known human coronaviruses, including SARS-CoV-2, cluster.
Diego Forni, Rachele Cagliani, Manuela Sironi   +2 more
doaj   +1 more source

Is HIV short-sighted? Insights from a multistrain nested model [PDF]

, 2013
An important component of pathogen evolution at the population level is evolution within hosts. Unless evolution within hosts is very slow compared to the duration of infection, the composition of pathogen genotypes within a host is likely to change ...
Lythgoe, KA, Pellis, Lorenzo; id_orcid, Lythgoe, Katrina A., Pellis, L, Lythgoe, Katrina Abigail, Pellis, Lorenzo, Fraser, C, Fraser, Christophe   +7 more
core   +1 more source

Unveiling Crucivirus Diversity by Mining Metagenomic Data

mBio, 2020
The discovery of cruciviruses revealed the most explicit example of a common protein homologue between DNA and RNA viruses to date. Cruciviruses are a novel group of circular Rep-encoding single-stranded DNA (ssDNA) (CRESS-DNA) viruses that encode capsid
Ignacio de la Higuera, George W. Kasun, Ellis L. Torrance, Alyssa A. Pratt, Amberlee Maluenda, Jonathan Colombet, Maxime Bisseux, Viviane Ravet, Anisha Dayaram, Daisy Stainton, Simona Kraberger, Peyman Zawar-Reza, Sharyn Goldstien, James V. Briskie, Robyn White, Helen Taylor, Christopher Gomez, David G. Ainley, Jon S. Harding, Rafaela S. Fontenele, Joshua Schreck, Simone G. Ribeiro, Stephen A. Oswald, Jennifer M. Arnold, François Enault, Arvind Varsani, Kenneth M. Stedman   +26 more
doaj   +1 more source

Evolution and Vaccination of Influenza Virus [PDF]

Journal of Computational Biology, 2017
In this study, we present an application paradigm in which an unsupervised machine learning approach is applied to the high-dimensional influenza genetic sequences to investigate whether vaccine is a driving force to the evolution of influenza virus. We first used a visualization approach to visualize the evolutionary paths of vaccine-controlled and ...
Ham Ching Lam, Xuan Bi, Srinand Sreevatsan, Daniel Boley   +3 more
openaire   +2 more sources

Immunoinformatic Analysis Reveals Antigenic Heterogeneity of Epstein-Barr Virus Is Immune-Driven

Frontiers in Immunology, 2021
Whole genome sequencing of Epstein-Barr virus (EBV) isolates from around the world has uncovered pervasive strain heterogeneity, but the forces driving strain diversification and the impact on immune recognition remained largely unknown.
Ana Cirac, Ana Cirac, Remy Poirey, Michael Dieckmeyer, Klaus Witter, Henri-Jacques Delecluse, Uta Behrends, Uta Behrends, Uta Behrends, Josef Mautner, Josef Mautner, Josef Mautner   +11 more
doaj   +1 more source

Intrahost evolution of the HIV-2 capsid correlates with progression to AIDS [PDF]

, 2022
HIV-2 infection will progress to AIDS in most patients without treatment, albeit at approximately half the rate of HIV-1 infection. HIV-2 capsid (p26) amino acid polymorphisms are associated with lower viral loads and enhanced processing of T cell ...
da Silva, Z.J., Boswell, M. T., Jansson, M, Nazziwa, J., Medstrand, P, A Palm, da Silva, ZJ, Biague, A, Månsson, F., de Silva, T I, Norrgren, H., K Maenaka, Jaye, A, Biague, A., Onyango, CO, C O Onyango, Medstrand, P., Palm, A, Kuroki, K, Palm, A., H Norrgren, Nazziwa, J, de Silva, TI, Maenaka, K., P Medstrand, Månsson, F, Rowland-Jones, SL, Onyango, C. O., K Kuroki, F Månsson, Maenaka, K, da Silva, Z J, Esbjörnsson, J, Boswell, M.T., Rowland-Jones, S.L., Kuroki, K., Norrgren, H, T I de Silva, Esbjörnsson, J., Boswell, MT, Onyango, C.O., Rowland-Jones, S. L., Karlson, S., A Biague, Jaye, A., Karlson, S, Rowland-Jones, S L, Boswell, M T, Jansson, M., S Karlson, J Nazziwa, de Silva, T.I., S L Rowland-Jones, J Esbjörnsson, da Silva, Z. J., Onyango, C O, de Silva, T. I., M Jansson, A Jaye, M T Boswell, Z J da Silva, Lund University., Sweden Guinea-Bissau Cohort Research (SWEGUB CORE) group   +62 more
core   +1 more source

Participation of Multifunctional RNA in Replication, Recombination and Regulation of Endogenous Plant Pararetroviruses (EPRVs)

Frontiers in Plant Science, 2021
Pararetroviruses, taxon Caulimoviridae, are typical of retroelements with reverse transcriptase and share a common origin with retroviruses and LTR retrotransposons, presumably dating back 1.6 billion years and illustrating the transition from an RNA to ...
Katja R. Richert-Pöggeler, Kitty Vijverberg, Kitty Vijverberg, Osamah Alisawi, Gilbert N. Chofong, J. S. (Pat) Heslop-Harrison, J. S. (Pat) Heslop-Harrison, Trude Schwarzacher, Trude Schwarzacher   +8 more
doaj   +1 more source

In vivo evidence for quasispecies distributions in the bovine respiratory syncytial virus genome [PDF]

, 2007
We analyzed the genetic evolution of bovine respiratory syncytial virus (BRSV) isolate W2-00131, from its isolation in bovine turbinate (BT) cells to its inoculation in calves.
Mirandette, Carole, Schelcher, François, Bonnet, Marion, Meyer, Gilles, Deplanche, Martine, Lemaire, Mylène   +5 more
core   +1 more source