Results 61 to 70 of about 961,541 (308)

Silencing the Autophagy-Related Genes ATG3 and ATG9 Promotes SRBSDV Propagation and Transmission in Sogatella furcifera

Insects, 2022
Autophagy plays diverse roles in the interaction among pathogen, vector, and host. In the plant virus and insect vector system, autophagy can be an antiviral/pro-viral factor to suppress/promote virus propagation and transmission.
Dandan Liu, Zhengxi Li, Maolin Hou
doaj   +1 more source

Is the United States Prepared for a Major Zika Virus Outbreak? [PDF]

, 2016
Zika virus has emerged as a global public health crisis with active transmission in the Americas and Caribbean. The World Health Organization (WHO) declared a Public Health Emergency of International Concern (PHEIC), and recently WHO reported there is a ...
Gostin, Lawrence O., Hodge, James G., Jr.   +1 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Metatranscriptome Analysis of Sympatric Bee Species Identifies Bee Virus Variants and a New Virus, Andrena-Associated Bee Virus-1

Viruses, 2021
Bees are important plant pollinators in agricultural and natural ecosystems. High average annual losses of honey bee (Apis mellifera) colonies in some parts of the world, and regional population declines of some mining bee species (Andrena spp.), are ...
Katie F. Daughenbaugh, Idan Kahnonitch, Charles C. Carey, Alexander J. McMenamin, Tanner Wiegand, Tal Erez, Naama Arkin, Brian Ross, Blake Wiedenheft, Asaf Sadeh, Nor Chejanovsky, Yael Mandelik, Michelle L. Flenniken   +12 more
doaj   +1 more source

Evaluation of the epidemiological importance of classical swine fever infected, E2 sub-unit marker vaccinated animals with RT-nPCR positive blood samples [PDF]

, 2005
<p>It has been demonstrated that pigs that have been double vaccinated with an E2 sub-unit marker vaccine and that are infected with classical swine fever virus (CSFV) through a natural contact infection may react positive in a CSFV detecting RT ...
Dewulf, Jeroen, HAEGEMAN, A, KOENEN, F, KRUIF, A, Laevens, Hans, Ribbens, Stefaan   +5 more
core   +2 more sources

Mayaro Virus Pathogenesis and Transmission Mechanisms [PDF]

Pathogens, 2020
Mayaro virus (MAYV), isolated for the first time in Trinidad and Tobago, has captured the attention of public health authorities worldwide following recent outbreaks in the Americas. It has a propensity to be exported outside its original geographical range, because of the vast distribution of its vectors.
Diagne, Cheikh Tidiane, Bengue, Michèle, Choumet, Valérie, Hamel, Rodolphe, Pompon, Julien, Missé, Dorothée   +5 more
openaire   +5 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Phylogeography of Japanese encephalitis virus:genotype is associated with climate [PDF]

, 2013
The circulation of vector-borne zoonotic viruses is largely determined by the overlap in the geographical distributions of virus-competent vectors and reservoir hosts.
A Igarashi, A Oya, A Rambaut, A Rambaut, AB Sabin, AJ Auguste, AJ Drummond, AJ Drummond, AJ Schuh, AJ Schuh, AJ Schuh, Alan D. T. Barrett, Amy C. Morrison, Amy J. Schuh, Andrew J. Leigh Brown, B Shapiro, BJ Smith, D Martin, D Posada, DP Martin, DP Martin, EK Cruickshank, EL Buescher, EL Buescher, EL Buescher, EL Buescher, EL Buescher, FA Rey, FJ May, G Baele, GL Campbell, GM Jenkins, H Tsuchie, H Weissenbock, HS Hurlbut, HY Wang, J Fox, J Parker, JE Bryant, JH Nam, JL Wang, JM Smith, JN Hanna, L Lewis, L Rosen, L Rosen, L Rosen, M Gouy, M Padidam, MA Mohammed, MA Suchard, Melissa J. Ward, MH Li, N Nitatpattana, P Lemey, PD Uchil, PT Nga, PV Fulmali, R Takhampunya, RS Lanciotti, S Guindon, S Kumar, SE Sulkin, SE Sulkin, SL Kosakovsky Pond, SL Kosakovsky Pond, SL Pond, SL Pond, SP Ma, T Bakonyi, T Mitamura, T Solomon, TJ Chambers, WF Scherer, WF Scherer, WF Scherer, WM Hammon, WR Chen, WR Chen, WS Paul, XL Pan, Y Kobayashi, YX Li, YY Chen   +83 more
core   +3 more sources

Chikungunya Virus Transmission

, 2022
Chikungunya virus (CHIKV) is a mosquito-borneAlphavirus that causes Chikungunya fever (CHIKF) in humans. In 1952, the CHIKV was found in East Africa in a sylvatic and urban cycle between Aedes mosquitoes, and human and nonhuman primates in tropical regions. Since 2004, CHIKF has spread rapidly in Asia, Africa, Europe, and the Americas.
openaire   +3 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source