Results 211 to 220 of about 205,339 (347)

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Peste des petits ruminants virus virulence is associated with an early inflammatory profile in the tonsils and cell cycle arrest in lymphoid tissue. [PDF]

Microbiol Spectr
Eloiflin R-J, Grau-Roma L, Lasserre V, Python S, Talker S, Totte P, García-Nicolás O, Summerfield A, Bataille A.   +8 more
europepmc   +1 more source

Host phylogenetic distance drives trends in virus virulence and transmissibility across the animal-human interface. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2019
Guth S, Visher E, Boots M, Brook CE.
europepmc   +1 more source

Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection [PDF]

, 2017
Julie McAuley, Yi‐Mo Deng, Brad Gilbertson, Charley Mackenzie-Kludas, Ian Barr, Lorena E. Brown   +5 more
openalex   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice. [PDF]

BMC Genomics, 2019
Ivan FX, Kwoh CK.
europepmc   +1 more source

Codon Usage Determines the Mutational Robustness, Evolutionary Capacity, and Virulence of an RNA Virus [PDF]

, 2012
Adam S. Lauring, Ashley Acevedo, Samantha Cooper, Raul Andino   +3 more
openalex   +1 more source

The impact of accumulating immune adaptation in circulating strains of HIV‐1

HIV Medicine, EarlyView.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi, Alison Castley, Pooja Deshpande, Abha Chopra, David Nolan, Simon Mallal, Mina John, Silvana Gaudieri   +7 more
wiley   +1 more source

The African Swine Fever Virus Virulence Determinant DP96R Suppresses Type I IFN Production Targeting IRF3. [PDF]

Int J Mol Sci
Dodantenna N, Cha JW, Chathuranga K, Chathuranga WAG, Weerawardhana A, Ranathunga L, Kim Y, Jheong W, Lee JS.   +8 more
europepmc   +1 more source