Results 111 to 120 of about 2,202,818 (359)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair +17 morewiley +1 more sourceParainfluenza Viruses [PDF]
Clinical Microbiology Reviews, 2003 SUMMARYHuman parainfluenza viruses (HPIV) were first discovered in the late 1950s. Over the last decade, considerable knowledge about their molecular structure and function has been accumulated. This has led to significant changes in both the nomenclature and taxonomic relationships of these viruses.openaire +2 more sourcesLINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico +12 morewiley +1 more sourceGlobal prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study [PDF]
, 2016 Sarah Blach, Stefan Zeuzem, Michael P. Manns, Ibrahim Altraif, Ann‐Sofi Duberg, David Handojo Muljono, Imam Waked, Seyed M Alavian, Mei–Hsuan Lee, Francesco Negro, Faisal Abaalkhail, Ahmed Ms Abdou, Maheeba Abdulla, Antoine Abou Rached, Inka Aho, Ulus Salih Akarca, Imad Ghazzawi, Saad Al Kaabi, Faryal Al Lawati, Khalid Al Namaani, Y. Al Serkal, Said A. Al‐Busafi, L. Al‐Dabal, Soo Aleman, Abdullah Alghamdi, Abdulrahman Aljumah, Hamad Eid Al‐Romaihi, Monique Andersson, Vic Arendt, Perttu Arkkila, Abdullah M. Assiri, Oidov Baatarkhuu, Abate Bane, Ziv Ben‐Ari, Colm Bergin, Fernando Bessone, Florian Bihl, Abdul Rahman Bizri, Martin Blachier, Antonio Javier Blasco, Carlos Eduardo Brandão‐Mello, Philip Bruggmann, Cheryl Brunton, Filipe Calinas, Henry Lik‐Yuen Chan, Asad Chaudhry, Hugo Cheinquer, Chien‐Jen Chen, Rong‐Nan Chien, Moon Seok Choi, Peer Brehm Christensen, Wan‐Long Chuang, Vladimir Chulanov, Laura Cisneros, Mette Rye Clausen, Matthew Cramp, Antonio Craxı̀, Esther A. Croes, Olav Dalgård, Jorge Daruich, Victor de Lédinghen, Gregory J. Dore, Manal H. El‐Sayed, Gül Ergör, Gamal Esmat, Chris Estes, Karolin Falconer, Elmoubasher Farag, Maria Lúcia Gomes Ferraz, Paulo Roberto Abrão Ferreira, Robert Flisiak, Soňa Fraňková, Ivane Gamkrelidze, Ed Gane, Javier García‐Samaniego, Amir Ghafoor Khan, Ilias Gountas, Adrian Goldis, Magnús Gottfreðsson, Jason Grebely, Michael Gschwantler, Mário Guimarães Pessôa, J. Gunter, Behzad Hajarizadeh, O. Hajelssedig, Saeed Hamid, Waseem Hamoudi, Angelos Hatzakis, Sayed Himatt, Harald Hofer, Irena Hrstić, Yee-Tak Hui, Béla Hunyady, Ramazan Idılman, Wasim Jafri, Rohani Jahis, Naveed Z. Janjua, Peter Jarčuška, Agita Jēruma, Jón G. Jónasson +99 moreopenalex +1 more sourceGenomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses [PDF]
, 2020 Martin Kapun, Maite G. Barrón, Fabian Staubach, Darren J. Obbard, R Axel W Wiberg, Jorge Vieira, Clément Goubert, Omar Rota‐Stabelli, Maaria Kankare, María Bogaerts-Márquez, Annabelle Haudry, Lena Waidele, Iryna Kozeretska, E. G. Pasyukova, Volker Loeschcke, Marta Pascual, Cristina P. Vieira, Svitlana Serga, Catherine Montchamp‐Moreau, Jessica K. Abbott, Patricia Gibert, Damiano Porcelli, Nico Posnien, Alejandro Sánchez‐Gracia, Sonja Grath, Élio Sucena, Alan O. Bergland, Maria Pilar García Guerreiro, Banu Şebnem Önder, Eliza Argyridou, Lain Guio, Mads F. Schou, Bart Deplancke, Cristina Vieira, Michael G. Ritchie, Bas J. Zwaan, Eran Tauber, Dorcas J. Orengo, Eva Puerma, Montserrat Aguadé, Paul Schmidt, John Parsch, Andrea J. Betancourt, Thomas Flatt, Josefa González +44 moreopenalex +1 more sourceDeveloping evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking +43 morewiley +1 more sourceInfluenza viruses – antiviral therapy and resistance
GMS Infectious Diseases, 2017 Influenza is a serious and frequently underestimated, but vaccine preventable disease. The adamantane derivates rimantadine and amantadine and the neuraminidase inhibitors zanamivir and oseltamivir are the only antiviral drugs currently approved in ...Duwe, Susannedoaj +1 more sourceGlobal shifts in mammalian population trends reveal key predictors of virus spillover risk. [PDF]
, 2020 Emerging infectious diseases in humans are frequently caused by pathogens originating from animal hosts, and zoonotic disease outbreaks present a major challenge to global health.Doyle, Megan M, Evans, Tierra Smiley, Hitchens, Peta L, Johnson, Christine K, Pandit, Pranav S, Rushmore, Julie, Young, Cristin CW +6 morecore Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn +11 morewiley +1 more source
