Results 231 to 240 of about 3,207,629 (358)

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Antiviral susceptibility of clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses from humans in the United States, October 2024 to February 2025. [PDF]

Emerg Microbes Infect
Pascua PNQ, Chesnokov AP, Nguyen HT, Champion C, Gao R, De La Cruz JA, Jang Y, Hatta Y, Guo Z, Uyeki TM, Di H, Stevens J, Davis CT, Gubareva LV.   +13 more
europepmc   +1 more source

Intraepithelial γδ T Cells May Bridge a Gap between Innate Immunity and Acquired Immunity to Herpes Simplex Virus Type 2

, 2004
Hitoshi Nishimura, Toshiki Yajima, Yoshiko Kagimoto, Mutsuhiro Ohata, Taketo Watase, Kenji Kishihara, Fumi Goshima, Yukihiro Nishiyama, Yasunobu Yoshikai   +8 more
openalex   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Viral surveillance of invasive mammals in New Zealand reveals unique viral lineages reflecting their introduction history. [PDF]

J Virol
French RK, Pichlmueller F, Waller SJ, Dubrulle J, Tuxford J, Veale A, Geoghegan JL.   +6 more
europepmc   +1 more source

4D Mapping of ZIF Biocomposites for High Protein Loading and Tunable Release Profiles

Advanced Functional Materials, EarlyView.
Systematic four‐dimensional mapping of zeolitic imidazolate framework biocomposites reveals how precursor ratios, total concentration, and washing define crystalline phase, protein loading, and release kinetics. This comprehensive study identifies conditions yielding record loading (∼85%) and precise phase–property correlations.
Michael R. Hafner, Francesco Carraro, Behnaz Abbasgholi‐NA, Simone Dal Zilio, Max Schmallegger, Helmar Wiltsche, Lingcong Ge, Michael R. Reithofer, Efwita Astria, Laura Villanova, Heinz Amenitsch, Christian Doonan, Paolo Falcaro   +12 more
wiley   +1 more source

SMAD proteins of oligodendroglial cells regulate transcription of JC virus early and late genes coordinately with the Tat protein of human immunodeficiency virus type 1

, 2009
Michelle R. Stettner, Jonas A. Nance, Clayton Wright, Yayoi Kinoshita, Woong‐Ki Kim, Susan Morgello, Jay Rappaport, Kamel Khalili, Jennifer Gordon, Edward M. Johnson   +9 more
openalex   +2 more sources

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Targeting Host Dependency Factors: A Paradigm Shift in Antiviral Strategy Against RNA Viruses. [PDF]

Int J Mol Sci
Yang J, Qu Y, Yuan Z, Lun Y, Kuang J, Shao T, Qi Y, Li Y, Zhu L.   +8 more
europepmc   +1 more source

Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir

, 2012
Adriano Ferrucci, Michael R. Nonnemacher, Éric A. Cohen, Brian Wigdahl   +3 more
openalex   +2 more sources