Results 271 to 280 of about 3,729,339 (351)

Dissolving Microneedle for Maintaining the Integrity of HPV Virus‐Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues

Advanced Healthcare Materials, EarlyView.
A novel dissolving microneedle platform preserves HPV virus‐like particle (VLP) immunogenicity by maintaining structural integrity, crucial for eliciting potent immune responses. Buccal administration induces robust immune response, high neutralizing antibody titers, and durable sterile protection across oral and vaginal mucosal sites.
Hyemi Kim, Inhyuk Hwang, Juhee Seo, Chaiwon Kim, In‐Jeong Choi, Miran Kang, Min‐Seok Rha, Youngjae Hong, Jooyoung Kim, Seung‐Ki Baek, Jung‐Hwan Park, Hyung‐Ju Cho, Kihyuck Kwak   +12 more
wiley   +1 more source

Epitope-Specific Antibody Immunodominance Driving Antibody and Influenza Viral Evolution During 2010- 2024. [PDF]

Open Forum Infect Dis
Lu X, Liu F, Tzeng WP, Zheng XY, Tumpey TM, York IA, Kondor RJ, Levine MZ.   +7 more
europepmc   +1 more source

Computer Viruses and Information Security [PDF]

, 2014
Kryvoi, Vladlen, Mieshkov, V. I., Poperechna, N.V.   +2 more
core  

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Characterization of H9N2 avian influenza virus isolated from chickens and waterfowl in parts of Southern China from 2018 to April 2024. [PDF]

Poult Sci
Zhou W, He J, Qiao F, Wang M, Zeng Q, Liu Y, Zhao Y, Zhang L, Li T, Du S, Sun M, Liao M.   +11 more
europepmc   +1 more source

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Gold nanoparticle-based delivery of Cas13d for targeted RNA virus defense. [PDF]

Mol Ther Nucleic Acids
Alves da Silva NJ, Rodrigues Alves MT, França FA, Guimarães PPG.   +3 more
europepmc   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Oral and Faecal Viromes of New Zealand Calves on Pasture With an Idiopathic Ill-Thrift Syndrome. [PDF]

Transbound Emerg Dis
Grimwood RM, Darnley JA, O'Connell JP, Hunt H, Taylor HS, Lawrence KE, Abbott MBW, Jauregui R, Geoghegan JL.   +8 more
europepmc   +1 more source