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The Origin and Evolution of Viruses as Molecular Organisms [PDF]
, 2009 Viruses are the most abundant life forms and the repertoire of viral genes is greater than that of cellular genes. It is also evident that viruses have played a major role in driving cellular evolution, and yet, viruses are not part of mainstream biology,
Claudiu I. Bandea
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The evolution of genome compression and genomic novelty in RNA viruses [PDF]
, 2007 The genomes of RNA viruses are characterized by their extremely small size and extremely high mutation rates ( typically 10 kb and 10(-4)/ base/ replication cycle, respectively), traits that are thought to be causally linked.
Rambaut, Andrew +2 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
HCIV-1 and other tailless icosahedral internal membrane-containing viruses of the family Sphaerolipoviridae [PDF]
, 2017 Members of the virus family Sphaerolipoviridae include both archaeal viruses and bacteriophages that possess a tailless icosahedral capsid with an internal membrane.
Svirskaite, Julija +19 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Molecular biology of giant viruses' DNA replication machinery [PDF]
, 2013 Viruses are the most widespread and abundant entity on this planet, further constituting the largest part of the genosphere. The majority of these infectious agents are miniature, having been described as being smaller than the smallest bacteria.
Evripioti, Antonia Alexandra
core
Distribution of TT virus (TTV), TTV-like minivirus, and related viruses in humans and nonhuman primates [PDF]
, 2003 TT virus (TTV) and TTV-like minivirus (TLMV) are small DNA viruses with single-stranded, closed circular, antisense genomes infecting man. Despite their extreme sequence heterogeneity (>50%), a highly conserved region in the untranslated region (UTR ...
Thom, K +4 more
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Virulence during Newcastle Disease Viruses Cross Species Adaptation [PDF]
, 2021 The hypothesis that host adaptation in virulent Newcastle disease viruses (NDV) has been accompanied by virulence modulation is reviewed here. Historical records, experimental data, and phylogenetic analyses from available GenBank sequences suggest that ...
Claudio L. Afonso
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Proceedings of the National Academy of Sciences, 2014 A herpes virus snakes its way around the bookshelves of the State Library of Victoria, Australia, accompanied by music composed for the occasion. Image courtesy of Drew Berry.
openaire +2 more sources