Results 81 to 90 of about 183,360 (258)

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Sex-Specific Misclassification of Obesity When Using Body Mass Index in Young Healthcare Professionals: A Large Cross-Sectional Study Using Multiple Adiposity Indices

Medical Sciences
Background: Body mass index (BMI) remains the standard tool for obesity screening; however, it does not account for body fat distribution or visceral adiposity, potentially leading to clinically relevant misclassification—particularly in young adults ...
Alberto Ramirez Gallegos, Pedro Juan Tárraga López, Mónica Silu Piña Dabreu, Lluis Rodas Cañellas, Ángel Arturo López-González, José Ignacio Ramírez-Manent   +5 more
doaj   +1 more source

Renin inhibition improves metabolic syndrome, and reduces angiotensin II levels and oxidative stress in visceral fat tissues in fructose-fed rats.

PLoS ONE, 2017
Renin-angiotensin system in visceral fat plays a crucial role in the pathogenesis of metabolic syndrome in fructose-fed rats. However, the effects of renin inhibition on visceral adiposity in metabolic syndrome are not fully investigated. We investigated
Chu-Lin Chou, Heng Lin, Jin-Shuen Chen, Te-Chao Fang   +3 more
doaj   +1 more source

Significance of the Visceral Adiposity Index and Other Indicators in Identifying Metabolic Subtypes

Objective: Metabolic phenotypes associated with high cardiovascular risk have been described. The visceral adiposity index (VAI) is a simple indicator of increased visceral adipose tissue using anthropometric and lipid parameters.
Fatma Nur Korkmaz, Demet Çorapçıoğlu, Asena Gökçay Canpolat   +2 more
core   +1 more source

Gender-specific anthropometric markers of adiposity, metabolic syndrome and visceral adiposity index (VAI) in patients with obstructive sleep apnea

, 2014
Obstructive sleep apnea often coexists with visceral adiposity and metabolic syndrome. In this study, we analysed gender-related differences in anthropometrics according to sleep apnea severity and metabolic abnormalities.
MAZZUCA, Emilia, Marrone, O, Barbé, F, BONSIGNORE, Maria Rosaria, MAROTTA, Anna Maria, BATTAGLIA, Salvatore, Barcelò, A, CASTROGIOVANNI, Alessandra, Esquinas, C   +8 more
core   +1 more source

Oral miltefosine for Indian visceral leishmaniasis. [PDF]

, 2002
BACKGROUND: There are 500,000 cases per year of visceral leishmaniasis, which occurs primarily in the Indian subcontinent. Almost all untreated patients die, and all the effective agents have been parenteral.
Berman, Jonathan, Thakur, C. P., Sundar, Shyam, Junge, Klaus, Thakur, CP, Bryceson, Anthony, Engel, Juergen, Sindermann, Herbert, Jha, TK, Jha, T. K., Fischer, Christina   +10 more
core   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

Visceral adiposity index as an indicator of cardiometabolic risk in patients treated for craniopharyngioma

, 2017
Purpose: Craniopharyngioma is associated with metabolic alterations leading to increased cardiovascular mortality. Recently, the visceral adiposity index has been proposed as a marker of visceral adipose tissue dysfunction and of the related ...
RUSSO, GIUSEPPINA, Spagnolo, F, AVERSA, TOMMASO, TRIMARCHI, Francesco, COTTA, OANA RUXANDRA, CANNAVO', LAURA, CANNAVO', Salvatore, FERRAU', FRANCESCO, ALIBRANDI, Angela   +8 more
core   +1 more source

Dietary predictors of visceral adiposity in overweight young adults [PDF]

, 2010
The purpose of the present study was to determine the dietary predictors of visceral adipose tissue (VAT) area in overweight young adults. A total of 109 young adults (fifty males and fifty-nine females) ate ad libitum in a university cafeteria for 14 d.
Donnelly, Joseph E., Kirk, Erik P., Sullivan, Debra K., Bailey, Bruce W.   +3 more
core   +1 more source

Video and Text‐Based Supplemental Health Information and Consumer Willingness to Pay for Nutrient‐Enhanced Eggs

Agribusiness, EarlyView.
ABSTRACT Nutritional information is very important in the food choices of consumers. However, when they are too scientific or technical, they have the potential to confuse consumers, resulting in information asymmetry and dissuading them from making beneficial choices.
Edeoba W. Edobor, Michael J. Best, Anita R. Best, Ondulla T. Toomer   +3 more
wiley   +1 more source