Results 111 to 120 of about 86,688 (248)

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Fundamental Neurochemistry Review: The role of enteroendocrine cells in visceral pain. [PDF]

J Neurochem, 2023
Londregan A, Alexander TD, Covarrubias M, Waldman SA.   +3 more
europepmc   +1 more source

Psychological Treatment for Pediatric Feeding Disorder (PFD) and Avoidant/Restrictive Food Intake Disorder (ARFID)

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective To produce a consensus statement on the psychological treatment of feeding/eating aversions seen in pediatric feeding disorder (PFD) and avoidant/restrictive food intake disorder (ARFID), diagnoses that share common symptoms and psychological mechanisms but have historically been addressed separately in the literature. Method To help
Colleen T. Lukens, Robert M. Dempster, Kamryn T. Eddy, Hayley Estrem, Jessie E. Menzel, Richard J. Noel, Jaclyn L. Pederson, Ana L. Ramirez, Cuyler Romeo, William G. Sharp, Jennifer J. Thomas, Nancy L. Zucker, Hana F. Zickgraf   +12 more
wiley   +1 more source

From Epithelial Sensing to Visceral Pain: Neuropod and Enterochromaffin Cells in Gut Neuroepithelial Circuits. [PDF]

Int J Mol Sci
Nowacka A, Śniegocki M, Ziółkowska EA.   +2 more
europepmc   +1 more source

Direct cortical stimulation–evoked symptoms in the human temporal pole: A systematic review

Epileptic Disorders, EarlyView.
Abstract The temporal pole represents a key node within temporolimbic networks and may contribute to seizure generation in temporal lobe epilepsy. Direct cortical stimulation (DCS), performed during intracranial presurgical evaluation, is a valuable method for delineating the seizure onset zone by reproducing electro‐clinical features of a patient's ...
Yulia Novitskaya, Andreas Schulze‐Bonhage   +1 more
wiley   +1 more source

Unraveling nocebo effects in visceral pain: negative suggestion and adverse treatment experience uniquely shape visceral pain unpleasantness. [PDF]

Pain
Aulenkamp JL, Pawlik RJ, Guddat C, Engler H, Kleine-Borgmann J, Icenhour A, Elsenbruch S.   +6 more
europepmc   +1 more source

An Ocular Surface‐Targeting Nucleic Acid Hydrogel for Efficient Dry Eye Disease Treatment

Exploration, EarlyView.
A self‐assembled nucleic acid hydrogel modified with mucin‐1 (MUC1) aptamer is developed, which can actively target the mucin layer on the ocular surface and significantly extend its retention time after distillation. Inside the hydrogel, therapeutic siRNA is embedded and can effectively silence the inflammation gene expression, subsequently restoring ...
Yuhe Liu, Zimeng Zhai, Yangyang Huang, Fujun Wang, Zifei Wang, Lijuan Zhu, Ka Jiang, Xujiao Zhou, Xingtao Zhou, Ying Jie, Xiuming Jin, Chuan Zhang, Jiaxu Hong   +12 more
wiley   +1 more source

Docosahexaenoic Acid Attenuates Visceral Pain by Suppressing Spinal CXCL10/CXCR3/ERK Signaling. [PDF]

Nutrients
Yin X, Jiang A, Han Y, Qu J, Zhao J, Gong H, Luo X, Li X, Lu Y.   +8 more
europepmc   +1 more source

Monitoring and assessment for obstructive sleep apnea

FlexMat, EarlyView.
This review systematically classifies Obstructive Sleep Apnea (OSA) monitoring indicators into three categories: physical, biochemical, and electrophysiological indicators, and lists several methods for each category. Abstract Obstructive sleep apnea (OSA) is a common chronic sleep‐disordered breathing disease characterized by recurrent upper airway ...
Yaowen Xu, Feifei Lin, Shujiao Chen, Zhen You, Shujing Zhu, Weiwei Zhao, Qiang Zhao   +6 more
wiley   +1 more source

Mechanism, Dose, and Administration of Dexmedetomidine in Managing Visceral Pain Associated With Surgery: A Narrative Review. [PDF]

Med Sci Monit
Tian R, Jiang Z, Zhou H, Wang Y.
europepmc   +1 more source