Results 71 to 80 of about 1,159,089 (346)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Induced Coherence, Vacuum Fields, and Complementarity in Biphoton Generation

open access: yes, 2014
We describe spontaneous parametric down-conversion experiments in which induced coherence across two coupled interferometers results in high-visibility single-photon interference.
Heuer, A., Menzel, R., Milonni, P. W.
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Influence of Driver's Experience on Textual Traffic Sign Efficiency Depending on Visibility

open access: yesPromet (Zagreb), 2012
The research objective is to study the influence of thedriver's experience on the efficiency of the textual traffic sign dependingon the visibility, that is on the weather conditions.
Senka Pašagić   +2 more
doaj   +1 more source

Optimal Generation of Pulsed Entangled Photon Pairs

open access: yes, 2006
We experimentally investigate a double-pass parametric down-conversion scheme for producing pulsed, polarization-entangled photon pairs with high visibility. The amplitudes for creating photon pairs on each pass interfere to compensate for distinguishing
Dirk Bouwmeester   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Building visibility when firms depend on suppliers: case of seafood producers in Vietnam

open access: yesJournal of International Economics and Management, 2017
This paper develops a model highlight the importance of visibility for mitigating supplier risk when a buying firm depends on the supplier. Our model has shown that visibility can be an important information-based capability for reducing the dependence ...
Vu Hung Nguyen, Hung Cuong Nguyen
doaj  

Application of Fuzzy Techniques for Determining the Operating Speed Based on Road Geometry

open access: yesPromet (Zagreb), 2012
The operating speed is certainly one of the most important variables in the management of road safety. Its determination has been refined in the last few years by means of experimental analyses that have also sanctioned its strong link with the context ...
Antonino D'Andrea, Orazio Pellegrino
doaj   +1 more source

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