Results 51 to 60 of about 29,656 (245)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Do Private Firms Benefit from Trading in the Private Securities Market?

The Journal of Entrepreneurial Finance, 2018
The trading of private securities has recently gained greater visibility and importance with the advent of organized, private security exchanges. This paper uses data on IPO firms that list on the SharesPost private securities exchange platform to ...
Robert Loveland, Eric Fricke, Sinan Goktan   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Multistage Dynamic Optimization with Different Forms of Neural-State Constraints to Avoid Many Object Collisions Based on Radar Remote Sensing

Remote Sensing, 2020
This article presents the possibility of helping navigators direct the movement of an object, while safely passing through other objects, using an artificial neural network and optimization methods. It has been shown that the best trajectory of an object
Józef Lisowski
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Endoscopic-assisted treatment of pediatric Eagle Syndrome: A case report

Acta Oto-Laryngologica Case Reports
To depict a novel surgical approach for treatment of refractory pediatric Eagle Syndrome. A retrospective chart review of one pediatric patient who underwent successful treatment of Eagle Syndrome with an endoscopic-assisted transoral approach to ...
Amy B. Leming, Dylan G. Vance, Zhen J. Huang   +2 more
doaj   +1 more source

Temporal Variation of Moose–Vehicle Collisions in Alaska

Human-Wildlife Interactions, 2020
Collisions between vehicles and wildlife have long been recognized to pose threats to motorists and wildlife populations. In addition to the risk of injury or mortality faced by the motorists involved in wildlife-vehicle collisions (WVCs), other drivers ...
Lucian R. McDonald, Terry A. Messmer, Michael R. Guttery   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

NEW WAYS OF PEER REVIEWING IN JOURNALS: OPEN REVIEW

Pensar en Movimiento, 2015
Technology has helped improve many aspects of the quality of publications: more visibility, greater access to sources of information and option to verify those sources, among others.
Andrea Mora-Campos
doaj   +1 more source