Results 61 to 70 of about 331,617 (278)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Horizontal hotels and similar accommodation – classification and franchising as an option for their international visibility

open access: yesSTRATEGICA 2016 – Opportunities and risks in the contemporary business environment, 2016
While accommodation networks are an older concept, the idea of widespread hotels (Italian Albergo / hotel diffuso) appeared in the 90s in Italy when abandoned buildings after an earthquake in Friuli were renovated and managed as tourism accommodations. Up to today, in Italy, there are 76 registered facilities of various dispersed accommodation.
Slivar, Iva   +2 more
openaire  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Multistage Dynamic Optimization with Different Forms of Neural-State Constraints to Avoid Many Object Collisions Based on Radar Remote Sensing

open access: yesRemote Sensing, 2020
This article presents the possibility of helping navigators direct the movement of an object, while safely passing through other objects, using an artificial neural network and optimization methods. It has been shown that the best trajectory of an object
Józef Lisowski
doaj   +1 more source

Potential future climatic conditions on tourists : a case study focusing on Malta and Venice [PDF]

open access: yes, 2015
The main purpose of this study is to quantify important climatic shifts that took place over Malta and Venice that could be considered as a determining factor on their choice as two prime tourist destinations.
Galdies, Charles
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Options for daytime monitoring of atmospheric visibility in optical communications [PDF]

open access: yes
Techniques for daytime detection of atmospheric transmission and cloud cover to determine the capabilities of future deep-space optical communications links are considered.
Cowles, K., Erickson, D.
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Temporal Variation of Moose–Vehicle Collisions in Alaska

open access: yesHuman-Wildlife Interactions, 2020
Collisions between vehicles and wildlife have long been recognized to pose threats to motorists and wildlife populations. In addition to the risk of injury or mortality faced by the motorists involved in wildlife-vehicle collisions (WVCs), other drivers ...
Lucian R. McDonald   +2 more
doaj   +1 more source

Improving citations of published articles [PDF]

open access: yes
Higher educational institutions are ranked according to the number of citations received for their published work. More the citations better is the ranking. Every researcher hence looks to improve the citation score for their published work. This article
Balasubramanian, Thiagarajan   +1 more
core  

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