Results 81 to 90 of about 331,617 (278)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Evaluation of options for a UK electronic thesis service: study report [PDF]

, 2006
The British Library (BL), JISC, UK HE institutions and CURL have funded an 18-month project to develop a national framework for the provision, preservation and open access to electronic theses produced in UK HE institutions.
Swan, A.
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Platform badges for civic communication: An interdisciplinary discussion of a risk mitigation measure pursuant to Art. 35 DSA

Internet Policy Review
To promote civility in public discourse on online platforms while respecting user freedoms, this paper explores a voluntary user badge system. By asking users to commit to civic norms of discourse, this system rewards their commitment with increased ...
Jan Rau, Jan-Ole Harfst, Tobias Mast
doaj   +1 more source

Resource Allocation in a Network-Based Cloud Computing Environment: Design Challenges

, 2013
Cloud computing is an increasingly popular computing paradigm, now proving a necessity for utility computing services. Each provider offers a unique service portfolio with a range of resource configurations.
Jammal, Manar, Ouda, Abdelkader, Shami, Abdallah, Sharkh, Mohamed Abu   +3 more
core   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source

Exploring contextual barriers and enablers for the potential involvement of voluntary sports clubs in social prescribing: a qualitative case study in Denmark

BMC Primary Care
Background Social prescribing necessitates not only effective referral processes from general practices and a linking mechanism to community service options but also a vibrant community and voluntary sector.
Lene Gissel Rasmussen, Rasmus Østergaard Nielsen, Louise Horne Brok, Jemma Hawkins, Per Kallestrup, Knud Ryom   +5 more
doaj   +1 more source

How do I expose the inferior alveolar nerve for microneurosurgical repair?

Oral and Maxillofacial Surgery Cases
This technical note describes an innovation that addresses a clinical problem in iatrogenic inferior alveolar nerve (IAN) repair. The options for IAN exposure (Miloro, 1995) are less than ideal since they offer limited access and visibility and/or the ...
Michael Miloro
doaj   +1 more source

Accidental child driveway runovers: Exploring Waikato data and the efficacy of existing responses [PDF]

, 2009
While the numbers of accidents are not high, there is little doubt that driveway runovers are an ongoing, often fatal and inevitably avoidable tragedy for children and their families. In many cases the driver is an immediate family member, or a neighbour
Campbell, Maxine M., Hunter, John, Poulgrain, Hayley Mills   +2 more
core   +1 more source