Results 51 to 60 of about 1,601,730 (258)

LensAge index as a deep learning-based biological age for self-monitoring the risks of age-related diseases and mortality

Nature Communications, 2023
Age is closely related to human health and disease risks. However, chronologically defined age often disagrees with biological age, primarily due to genetic and environmental variables.
Ruiyang Li, Wenben Chen, Mingyuan Li, Ruixin Wang, Lanqin Zhao, Yuanfan Lin, Xinwei Chen, Yuanjun Shang, Xueer Tu, Duoru Lin, Xiaohang Wu, Zhenzhe Lin, Andi Xu, Xun Wang, Dongni Wang, Xulin Zhang, Meimei Dongye, Yunjian Huang, Chuan Chen, Yi Zhu, Chunqiao Liu, Youjin Hu, Ling Zhao, Hong Ouyang, Miaoxin Li, Xuri Li, Haotian Lin   +26 more
doaj   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

The role of inflammation and fibroblasts in conjunctival scarring in ocular mucous membrane pemphigoid [PDF]

, 2009
Ocular mucous membrane pemphigoid (ocular MMP) is a visually devastating disease where up to 30% of patients become blind due to the consequences of conjunctival inflammation and aggressive fibrosis.
Saw, V.P.J.
core  

Congenital Aniridia and the Ocular Surface

, 2016
Aniridia is a congenital pan-ocular disorder caused by haplo-insufficiency of Pax6, a crucial gene for proper development of the eye. Aniridia affects a range of eye structures, including the cornea, iris, anterior chamber angle, lens, and fovea.
Fagerholm, Per,, Ihnatko, Robert,, Edén, Ulla, Lagali, Neil, Edén, Ulla,, Ihnatko, Robert, Fagerholm, Per, Lagali, Neil,   +7 more
core   +1 more source

Corneal backscatter as a biomarker for edema severity in Fuchs endothelial corneal dystrophy: a cross-sectional study

Eye and Vision
Background Fuchs endothelial corneal dystrophy (FECD) is characterized by progressive endothelial dysfunction and corneal edema. Reliable objective biomarkers for grading disease severity are currently evolving.
Maximilian Friedrich, Hyeck-Soo Son, Lasha-Giorgi Turava, Maximilian Hammer, Louise Blöck, Lizaveta Chychko, Timur Mert Yildirim, Gerd Uwe Auffarth, Victor Aristide Augustin   +8 more
doaj   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Common visual problems in children with disability [PDF]

, 2014
Children with disability are at a substantially higher risk of visual impairment (VI) (10.5% compared with 0.16%) but also of ocular disorders of all types, including refractive errors and strabismus.
Salt, A, Sargent, J
core  

Therapy of Ocular Behçet Disease

, 2014
Ocular involvement in Behcet disease (BD) is characterized by recurrent inflammatory attacks and spontaneous resolution of acute inflammatory signs.
Ilknur Tugal-Tutkun, BODAGHI, Bahram, Manfred Zierhut, Ahmet M. Abu El-Asrar, ZIERHUT, Manfred, Bahram Bodaghi, ABU EL-ASRAR, Ahmet M., Tugal-Tutkun, Ilknur   +7 more
core   +1 more source

Active trachoma and ocular Chlamydia trachomatis infection in two Gambian regions: on course for elimination by 2020? [PDF]

, 2009
BACKGROUND: Trachoma has been endemic in The Gambia for decades. National trachoma control activities have been in place since the mid-1980's, but with no mass antibiotic treatment campaign.
Chrissy H Roberts, Sarr Isatou, Esther Aryee, Edwards Tansy, Sillah Ansumana, Harding-Esch, Emma M, Sillah, Ansumana, Martin J Holland, Bailey Robin L., Molina, Sandra, Edwards, Tansy, Harding-Esch Emma M., Sandra Molina, David C W Mabey, Emma M Harding-Esch, Isatou Sarr, Snell Paul, Paul Snell, Tansy Edwards, Ansumana Sillah, Mabey David C. W., Roberts Chrissy H., Robin L Bailey, Bailey, Robin L, Holland, Martin J, Snell, Paul, Roberts, Chrissy H, Aryee Esther, Sarr, Isatou, Molina Sandra, Holland Martin J., Mabey, David CW, Aryee, Esther   +32 more
core   +1 more source