Results 41 to 50 of about 377,482 (306)

Reversal learning is influenced by cognitive flexibility and develops throughout early adolescence

npj Science of Learning
Learning behavioural responses and adapting them based on feedback is crucial from a young age, continuing to develop into young adulthood. This study examines the development trajectory and contributing factors from childhood to adulthood using a ...
Christoph Bamberg, Sarah Weigelt, Klara Hagelweide   +2 more
doaj   +1 more source

Lack of Association of rs1192415 in TGFBR3-CDC7 With Visual Field Progression: A Cohort Study in Chinese Open Angle Glaucoma Patients

Frontiers in Genetics, 2018
To investigate the association of known candidate genes with the visual field (VF) progression of primary open angle glaucoma (POAG) in a Han Chinese population. We included 440 POAG patients in this study.
Yuhong Chen, Yuhong Chen, Yuhong Chen, Chen Qiu, Chen Qiu, Shaohong Qian, Junyi Chen, Xueli Chen, Li Wang, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun, Xinghuai Sun   +12 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Elimination of avoidable blindness due to cataract: where do we prioritize and how should we monitor this decade? [PDF]

, 2012
BACKGROUND: In the final push toward the elimination of avoidable blindness, cataract occupies a position of eminence for the success of the Right to Sight initiative. AIMS: Review existing situation and assess what monitoring indicators may be useful to
John, Neena, Murthy, Gudlavalleti VS, Pant, Hira B, Shamanna, Bindiganavale R   +3 more
core   +2 more sources

MicroRNA-21-5p from induced pluripotent stem cells promotes neuroprotection of retinal ganglion cells in optic nerve crush model

BMC Ophthalmology
Introduction Retinal ganglion cells (RGCs) are susceptible to degenerative conditions such as glaucoma and traumatic optic neuropathies, which lead to vision loss.
Qing Xia, Wei Chen, Jiawei Xiong, Xiaofen Mo   +3 more
doaj   +1 more source

Generation of an integration-free induced pluripotent stem cell line (FDEENTi003-A) from a patient with pathological myopia

Stem Cell Research, 2019
Pathological myopia (PM) is a major cause of irreversible vision impairment worldwide. We have successfully reprogrammed the peripheral blood mononuclear cells (PBMCs) from a PM patient to induced pluripotent stem cells and characterized their ...
Xinyue Bai, Xian-Jie Yang, Ling Chen
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Company-Wide Initiative to Improve Screening for Vision Impairment [PDF]

, 2017
Objectives: \u3e 1 out of 6 point up in knowledge of vision impairment & confidence in screening (6 questions; 1=strongly disagree to 7=strongly agree) 40% of clients will undergo vision screening Identify & resolve barriers to vision screening (4 ...
Christine Potvin, PhD, OTR/L, Marie, Levengood, OTR/L, MSCS, OTD, Tami   +1 more
core   +1 more source

Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis [PDF]

, 2017
Background: Global and regional prevalence estimates for blindness and vision impairment are important for the development of public health policies. We aimed to provide global estimates, trends, and projections of global blindness and vision impairment.
Aditi Das, Aditi Das, MD, Alain Bron, Alan Morse, Alan Robin, Alex Silvester, Alex Silvester, MD, Anu Mathew, April Ingram, Aries Arditi, Banu Bozkurt, Beatriz Munoz, Billy Hammond, Charlotte Joslin, David Friedman, David Musch, Donald Budenz, Dwight Stambolian, Feng Cai, Fernando Yaacov Pena, Flavio Hirai, George Lambrou, Gianni Virgili, Gretchen A Stevens, DSc, Gretchen Stevens, Gus Gazzard, Hans LIMBURG, Hans Limburg, PhD, Harry Quigley, Hua Gao, Hugh R Taylor, MD, Hugh Taylor, Iva Dekaris, Jaewan Choi, Jaime Tejedor, James Hejtmancik, James Tielsch, Jan van Meurs, Janet Leasher, Janet Leasher, OD, Janet Serle, Jennifer Lim, Jenny Deva, Jill Keeffe, Jill Keeffe, PhD, Jimmy Volmink, Jinan Saaddine, Joao Furtado, John H Kempen, MD, John Huang, John Kempen, Jonathan Javitt, Jost B Jonas, MD, Jost Jonas, Juan Carlos Silva, Judy Kim, Kaweh Mansouri, Kevin Frick, Konrad Pesudovs, Konrad Pesudovs, PhD, Kovin Naidoo, Kovin Naidoo, PhD, Lalit Dandona, Laura Dreer, Leon Ellwein, Luca Rossetti, Marcela Frazier, MARIA PALAIOU, Maria V Cicinelli, MD, Maria Vittoria Cicinelli, Mary Elizabeth Hartnett, Maurizio Battaglia Parodi, Miltiadis Tsilimbaris, Minguang He, Moncef Khairallah, Monte Del Monte, Murugesan Raju, MYA SANDAR, Nathan Congdon, Nina Tahhan, PhD, Ning-Li Wang, Pamela Sieving, Paolo Lanzetta, Peter Ackland, Peter Wiedemann, Pradeep Ramulu, Prof Rupert R A Bourne, MD, Rajesh Shetty, Rakhi Dandona, Reza Dana, Richard Wormald, Rita S Sitorus, Robert Casson, Rohit Khanna, Rohit Varma, Ronnie George, Rupert Bourne, Serge Resnikoff, Serge Resnikoff, MD, Seth R Flaxman, BA, Sheila West, Stephen Gichuhi, TASANEE BRAITHWAITE, Tasanee Braithwaite, MPH, Tien Wong, Tien Y Wong, PhD, Tueng Shen, Tunde Peto, Usha Chakravarthy, Van Charles Lansingh, Victor Gonzalez, Vinay Nangia, Ya Xing Wang, Yaniv Barkana, Yingfeng Zheng   +114 more
core   +10 more sources

Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalk

Stem Cell Research & Therapy
Background Stem cell-derived secreted factors could protect neurons in neurodegenerative disease or after injury. The exact neuroprotective components in the secretome remain challenging to discover.
Qing Xia, Kun-Che Chang, Yanan Sun, Michael Nahmou, Takahiko Noro, Yun Cheng, Xiangmei Kong, Xiaofen Mo, Jeffrey L. Goldberg, Suqian Wu   +9 more
doaj   +1 more source