Results 71 to 80 of about 349,442 (310)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Is the NEI-VFQ-25 a useful tool in identifying visual impairment in an elderly population? [PDF]

, 2006
BACKGROUND: The use of self-report questionnaires to substitute for visual acuity measurement has been limited. We examined the association between visual impairment and self reported visual function in a population sample of older people in the UK ...
Christopher G Owen, Alicja R Rudnicka, Liam Smeeth, Jennifer R Evans, Richard PL Wormald, Astrid E Fletcher, GS Rubin, SK West, EM Chia, CM Mangione, CM Mangione, BL Brody, HD Jampel, R Klein, S Coren, AT Broman, SH Paz, RW Massof, JR Evans, L Smeeth, PV McGraw, V Carstairs, World Health Organization, BW Rovner, AE Stuck, DC Minassian, RW Massof, RW Massof, RW Massof, J Brabyn, BE Klein, The Submacular Surgery Trials Research Group   +31 more
core   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Visual acuity and patient satisfaction at varied distances and lighting conditions after implantation of an aspheric diffractive multifocal one-piece intraocular lens

Clinical Ophthalmology, 2016
Daniel H Chang Empire Eye and Laser Center, Bakersfield, CA, USA Purpose: The aim of the study is to evaluate the visual acuity and patient satisfaction at varied distances under photopic and mesopic lighting conditions in patients bilaterally ...
Chang DH
doaj  

Evaluating Visual Acuity in the American Academy of Ophthalmology IRIS® Registry

Ophthalmology Science
Objective: To describe visual acuity data representation in the American Academy of Ophthalmology Intelligent Research in Sight (IRIS) Registry and present a data-cleaning strategy Design: Reliability and validity study.
Arthur Brant, MD, Natasha Kolomeyer, MD, Jeffrey L. Goldberg, MD, PhD, Julia Haller, MD, Cecilia S. Lee, MD, MS, Aaron Y. Lee, MD, MSCI, Alice C. Lorch, MD, MPH, Joan W. Miller, MD, Leslie Hyman, PhD, Suzann Pershing, MD, MS   +9 more
doaj   +1 more source

Differential visual acuity – A new approach to measuring visual acuity

Journal of Optometry, 2020
A novel type of acuity measurement, which we refer to as 'differential acuity', requires the observer to identify one unique target among three others which are identical. This is a proof of concept study aimed to determine if differential acuity is equivalent to standard measures of recognition acuity.To create a range of visual acuity, vision was ...
Leat, Susan J., Yakobchuk-Stanger, Cristina, Irving, Elizabeth L.   +2 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Visual Acuity of Four-Wheeled Public Transport Drivers in Jatinangor

Althea Medical Journal, 2018
Background: The number of motor vehicles usage is increasing every year, along with the increasing prevalence of motor vehicle accidents, and mortality due to traffic accidents in 2010.
Feranika Feranika, Reni Farenia, Nina Ratnaningsih   +2 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source