Results 41 to 50 of about 13,004 (278)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Detection of Migrainous Infarction with Formal Visual Field Testing: A Case Report

Clinical Practice and Cases in Emergency Medicine, 2020
Introduction: Cerebrovascular accidents (CVA) of the posterior circulation are a rare complication of migraine, and present with atypical CVA symptomatology.
William Bylund, Ross Patrick, Ann Macdonald   +2 more
doaj   +1 more source

Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras

Frontiers in Human Neuroscience, 2023
BackgroundThe migrainous aura has different clinical phenotypes. While the various clinical differences are well-described, little is known about their neurophysiological underpinnings.
Chiara Abagnale, Antonio Di Renzo, Gabriele Sebastianelli, Francesco Casillo, Emanuele Tinelli, Giada Giuliani, Maria Giulia Tullo, Mariano Serrao, Vincenzo Parisi, Marco Fiorelli, Francesca Caramia, Jean Schoenen, Vittorio Di Piero, Gianluca Coppola   +13 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Functional Magnetic Resonance Imaging for Investigating the Role of the Hippocampus in Migraine with Aura. [PDF]

Diagnostics (Basel)
Background/Objectives: Migraine with aura (MwA) is a heterogeneous disorder comprising pure visual aura (MwAv) and more complex phenotypes with additional somatosensory and/or dysphasic symptoms (MwAvsd).
Radović M, Daković M, Radojičić A, Petrušić I.   +3 more
europepmc   +2 more sources

Prevalence and characteristics of visual aura in idiopathic generalized epilepsy

, 2012
Some patients with idiopathic/genetic generalized epilepsy (IGE) experience visual aura, which can confuse the diagnosis. We sought to determine the frequency and characteristics of visual auras in IGE patients.
Gungor-Tuncer, Ozlem, Bebek, Nerses, Altindag, Ebru, Gurses, Candan, Gokyigit, Aysen, Baykan, BETÜL   +5 more
core   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini, Alessia Casarini, Niccolò Biagioli, Laura Mirandola, Daniela Ballotta, Paul Summers, Simona Scolastico, Laura Madrassi, Maurilio Genovese, Marcella Malagoli, Gaetano Cantalupo, Giada Giovannini, Matteo Pugnaghi, Niccolò Orlandi, Laura Tassi, Valeria Cuccarini, Domenico Aquino, Elena Tartara, Fulvia Palesi, Giuseppe Didato, Paolo Vitali, the 3TLE Study Group, Roberta Di Giacomo, Fabio Doniselli, Federica Mazzi, Carlo Andrea Galimberti, Claudia A. M. Gandini Wheeler‐Kingshott, Stefano Meletti, Anna Elisabetta Vaudano   +28 more
wiley   +1 more source

Visual evoked potentials in subgroups of migraine with aura patients [PDF]

, 2015
BACKGROUND: Patients suffering from migraine with aura can have either pure visual auras or complex auras with sensory disturbances and dysphasia, or both.
Martelli, Francesco, Fadda, A., Coppola, G., Parisi, V., Pierelli, F., DI LORENZO, CHERUBINO, Di Lorenzo, C., SERRAO, Mariano, Fadda, Antonello, Tavares Alvares Serrão, Margarida, Di Lenola, Davide, Schoenen, Jean, Di Renzo, A., Di Lenola, D., Di Renzo, Antonio, Bracaglia, M., COPPOLA, GIANLUCA, Parisi, Vincenzo, PIERELLI, Francesco, Martelli, F., BRACAGLIA, MARTINA   +20 more
core   +1 more source

Reduced neurovascular coupling of the visual network in migraine patients with aura as revealed with arterial spin labeling MRI: is there a demand-supply mismatch behind the scenes?

The Journal of Headache and Pain
Background Although neuroimaging investigations have consistently demonstrated that “hyperresponsive” and “hyperconnected” visual cortices may represent the functional substrate of cortical spreading depolarization in patients with migraine with aura ...
Marcello Silvestro, Fabrizio Esposito, Alessandro Pasquale De Rosa, Ilaria Orologio, Francesca Trojsi, Lorenzo Tartaglione, Pablo García-Polo, Gioacchino Tedeschi, Alessandro Tessitore, Mario Cirillo, Antonio Russo   +10 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source