Results 321 to 330 of about 2,870,855 (432)

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

An Eccentricity Gradient Reversal across High-Level Visual Cortex. [PDF]

J Neurosci
Daniel-Hertz E, Yao JK, Gregorek S, Hoyos PM, Gomez J.   +4 more
europepmc   +1 more source

Evidence for long‐term functional plasticity in the visual cortex of adult cats

, 1982
Wolf Singer, Felix Tretter, U. Yinon
openalex   +2 more sources

Improving Adult Vision Through Pathway‐Specific Training in Augmented Reality

Advanced Science, EarlyView.
Traditional perceptual training approaches are limited by stimulus specificity, treatment efficacy, and patient compliance. A novel altered reality (AR) method is developed to enhance pathway‐specific functions in human adults while performing everyday activities.
Yige Gao, Yulian Zhou, Qing He, Wen Wen, Peng Zhang   +4 more
wiley   +1 more source

Increased Activity in Human Visual Cortex during Directed Attention in the Absence of Visual Stimulation

Neuron, 1999
S. Kastner, M. Pinsk, P. Weerd, R. Desimone, Leslie G. Ungerleider   +4 more
semanticscholar   +1 more source

Trifunctional Sialylation‐Based SF‐ZIF@NA Hydrogel for Selective Osteoclast Inhibition and Enhanced Bone‐Vessel Regeneration in Osteoporotic Bone Defects

Advanced Science, EarlyView.
This study introduces the SF‐ZIF@NA hydrogel system for osteoporotic bone defect treatment. The hydrogel inhibits osteoclast fusion by removing sialic acid and preserves the anabolic function of precursor osteoclasts (pOCs). It also releases Zn2⁺ in acidic conditions, promoting osteogenesis and angiogenesis.
Zhengrong Chen, Wenxin Yang, Yong Tang, Qianqian Dong, Kui Huang, Jiulin Tan, Jie Zhang, Juan Cai, Qixiu Yu, Qijie Dai, Jianzhong Xu, Shuquan Guo, Ce Dou, Fei Luo   +13 more
wiley   +1 more source

The pulvinar regulates plasticity in human visual cortex

Acquafredda M, Kurzawski JW, Biagi L, Tosetti M, Morrone MC, Binda P.   +5 more
europepmc   +1 more source

Sleep is necessary for experience-dependent sequence plasticity in mouse primary visual cortex. [PDF]

Sleep
Hosamane NS, Didouchevski AM, Malci A, Gavornik JP, Sidorov MS.   +4 more
europepmc   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Feature selectivity and invariance in marsupial primary visual cortex. [PDF]

J Physiol
Jung YJ, Almasi A, Sun S, Yunzab M, Baquier SH, Renfree M, Meffin H, Ibbotson MR.   +7 more
europepmc   +1 more source