Results 41 to 50 of about 314,097 (252)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
SensorsEmotion matching prediction between music and video segments is essential for intelligent mobile sensing systems, where multimodal affective cues collected from smart devices must be jointly analyzed for context-aware media understanding.
Zhibin Su +4 more
doaj +1 more source
Basket Weaving in Coastal Southern California: A Social History of Survivance
Arts, 2019 This article underscores the romanticization of basket weaving in coastal Southern California in the late nineteenth and early twentieth centuries and the survival of weaving knowledge.
Yve Chavez
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Perpetual Vanishing: Animal Lives in Contemporary Scottish Fiction
Humanities, 2019 Animals, writes Akira Mizuta Lippit, ‘exist in a state of perpetual vanishing’: they haunt human concerns, but rarely appear as themselves. This is especially notable in contemporary Scottish fiction.
Timothy C. Baker
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Spanishness and Race in North American Monumental Architecture
ArtsThe representation of Spain, and Spanishness in general, at sites of collective identity in the United States and Canada requires scholarly attention. Many monuments, which range from statues and museums to capitol buildings and national parks, continue ...
Lauren Beck
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Some aspects on the Pictures of the North
Nordlit: Tidsskrift i litteratur og kultur, 2008 The objectives of this article are to draw the attention to, in my view, two necessities in the field of research on illustrated travel literature. I will argue that in order to understand the nature of illustrated travel literature the research has to ...
Lennart Pettersson
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