Results 51 to 60 of about 314,097 (252)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Valdur Mikita and the return of the real: In search of any-spaces-whatever in Estonian forests

Sign Systems Studies
Around the turn of the millennium, a paradigm shift took place in Western arts and humanities. (Post)structuralism, which had focused on language, the signifier, the epistemological, receded, and both academic and artistic attention turned to the real ...
Sven Vabar
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

La obra de arte en la época del colapso medioambiental: fricciones, paradojas y bifurcaciones

Mayéutica: Revista Científica de Humanidades y Artes
Este artículo examina algunas paradojas presentes en las prácticas artísticas, el lenguaje y la narración comprometidos con el ambientalismo, a la vez que explora posibles bifurcaciones capaces de desafiar las actuales visiones hegemónicas del mundo ...
Jye O’ Sullivan, Ester Toribio-­Roura
doaj   +1 more source

A few remarks on the mechanisms of censorship in the PRL and the Third Republic of Poland

Acta Universitatis Lodziensis. Folia Litteraria Polonica, 2017
The purpose of the paper is to discuss the mechanism of censorship before and after 1990 when the mission of the communist Chief Control Bureau for Press, Publications and Performances (GUKPPiW) was terminated.
Jakub Dąbrowski
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Developing the ArchAIDE Application: A digital workflow for identifying, organising and sharing archaeological pottery using automated image recognition

Internet Archaeology, 2020
Pottery is of fundamental importance for understanding archaeological contexts, facilitating the understanding of production, trade flows, and social interactions.
Francesca Anichini, Francesco Banterle, Jaume Buxeda i Garrigós, Marco Callieri, Nachum Dershowitz, Nevio Dubbini, Diego Lucendo Diaz, Tim Evans, Gabriele Gattiglia, Katie Green, Maria Letizia Gualandi, Miguel Angel Hervas, Barak Itkin, Marisol Madrid i Fernandez, Eva Miguel Gascón, Michael Remmy, Julian Richards, Roberto Scopigno, Llorenç Vila, Lior Wolf, Holly Wright, Massimo Zallocco   +21 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Insult to Injury? Women and Mental Disorder in Italian Photography and Visual Culture. [PDF]

Violence Against Women, 2023
Hill SP.
europepmc   +1 more source