Results 91 to 100 of about 5,353,117 (301)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
2017 State of the Visual Resources Association [PDF]
, 2020 During the 2017 Annual Business Meeting of the Visual Resources Association in Louisville, Kentucky, the president highlighted the accomplishments and challenges of the Association in a state of the association presentation.
Green, Jen W.
core
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
RiCognizioniIn German, English influences are, of course, most evident in the lexicon, but also in syntax and in areas such as orthography and punctuation. From the point of view of their visibility, a study of phraseology seems particularly relevant for at least ...
Sabine Fiedler
doaj +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Seeing Surrogacy: Digital Image Quality & Student Visual Literacy [PDF]
, 2020 This paper expands upon a survey administered to undergraduate art students at the College for Creative Studies in Detroit. The survey sought to ascertain if students notice digitization artifacts within digital images and if they can discern whether the
Lazet, Amy
core
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
BuildingsPerceived landscape quality in historical and cultural districts is crucial for reconciling cultural heritage preservation with urban renewal. However, limited attention has been paid to whether street-level visual elements influence public esthetic ...
Hong Xu, Tingwei Yang, Zixuan Guo
doaj +1 more source
Visual homograph: A novel basic visual element [PDF]
Neurocomputing, 2016 Liyan Zhang, Ke Gao
openaire +2 more sources
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source