Results 31 to 40 of about 106,507 (261)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Visual Evoked Potential in Multiple Sclerosis

Advanced Medical Journal
Background and objectives: Multiple sclerosis, a neurological disease with or without optic neuritis may cause abnormal visual evoked potential finding.
Asia Ali Rashid , Kamaran Hasan Azeez, Bakhtiar Qadir Hamasalih   +2 more
doaj   +1 more source

Electrophysiological study of thyroid ocular disorders

Delta Journal of Ophthalmology, 2019
Purpose The aims of this study were to evaluate the visual evoked potential (VEP) changes in thyroid ocular disorders and to correlate between VEP latencies and thyroid hormones.
Mona Abdel Kader, Naglaa Abass
doaj   +1 more source

Age-related differences in the transient and steady state responses to different visual stimuli

Frontiers in Aging Neuroscience, 2022
ObjectiveBrain-computer interface (BCI) has great potential in geriatric applications. However, most BCI studies in the literature used data from young population, and dedicated studies investigating the feasibility of BCIs among senior population are ...
Xin Zhang, Yi Jiang, Yi Jiang, Wensheng Hou, Ning Jiang, Ning Jiang   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Diagnostic accuracy of isolated-check visual evoked potentials for glaucoma: a systematic review and meta-analysis

BMC Ophthalmology
Background The isolated-check visual evoked potential (ic-VEP) is an advanced electrophysiological technique that selectively evaluates the magnocellular pathway, enabling precise assessment of optic nerve damage and currently serving as a diagnostic ...
Yongran Li, Yanling Lu, Tulong Lin
doaj   +1 more source

P100 wave latency in anisometropic and esotropic amblyopia versus normal eyes

Journal of Ophthalmic & Vision Research, 2015
Purpose: To evaluate cortical activity using pattern visual evoked potentials (PVEPs) in patients with mild and moderate amblyopia (esotropic and anisometropic).
Saeedeh Hosseinmenni, Mohamad Reza Talebnejad, Ebrahim Jafarzadehpur, Ali Mirzajani, Enayatollah Osroosh   +4 more
doaj   +1 more source

Stimulus Design for Visual Evoked Potential Based Brain-Computer Interfaces

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2023
Visual stimuli design plays an important role in brain-computer interfaces (BCIs) based on visual evoked potentials (VEPs). Variations in stimulus parameters have been shown to affect both decoding accuracy and subjective perception experience, implying ...
Haoyin Xu, Sheng-Hsiou Hsu, Masaki Nakanishi, Yufan Lin, Tzyy-Ping Jung, Gert Cauwenberghs   +5 more
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source