Results 1 to 10 of about 1,045,094 (185)

Investigating Determinants and Evaluating Deep Learning Training Approaches for Visual Acuity in Foveal Hypoplasia

Ophthalmology Science, 2023
Purpose: To describe the relationships between foveal structure and visual function in a cohort of individuals with foveal hypoplasia (FH) and to estimate FH grade and visual acuity using a deep learning classifier. Design: Retrospective cohort study and
Volha V. Malechka, MD, Dat Duong, PhD, Keyla D. Bordonada, MD, Amy Turriff, MS, Delphine Blain, MS, MBA, Elizabeth Murphy, PhD, Wendy J. Introne, MD, Bernadette R. Gochuico, MD, David R. Adams, MD, PhD, Wadih M. Zein, MD, Brian P. Brooks, MD, PhD, Laryssa A. Huryn, MD, Benjamin D. Solomon, MD, Robert B. Hufnagel, MD, PhD   +13 more
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Visual acuity assessment of central retinal artery occlusion patients with or without paracentral acute middle maculopathy via OCT-A

BMC Ophthalmology, 2023
Purpose The association between paracentral acute middle maculopathy (PAMM) and visual acuity in patients with central retinal artery occlusion (CRAO) is still unclear.
Hongxia Gong, Bin Wu, Shiyong Xie
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Evolution of focal choroidal excavation in ABCA4-related retinopathy

American Journal of Ophthalmology Case Reports, 2022
Purpose: To report long-term evolution of unilateral focal choroidal excavation in a patient with ABCA4-related retinopathy. Observations: A 51-year-old female with ABCA4-related retinopathy developed a small juxtafoveal defect in Bruch's membrane in a ...
Matthew D. Benson, Carly B. Feldman, Wadih M. Zein   +2 more
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Extraction (DSX) from Erigeron breviscapus modulates outward potassium currents in rat retinal ganglion cells [PDF]

International Journal of Ophthalmology, 2015
AIM: To investigate the effect of DSX, an active component extracted from Erigeron breviscapus, on the voltage-gated outward K+ channel currents in rat retinal ganglion cells (RGCs) by using electrophysiological method, and to explore the possible ...
Shuo Yin, Zhong-Feng Wang, Jun-Guo Duan, Lu Ji, Xue-Jing Lu   +4 more
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Functional regulation of an outer retina hyporeflective band on optical coherence tomography images

Scientific Reports, 2021
Human and animal retinal optical coherence tomography (OCT) images show a hyporeflective band (HB) between the photoreceptor tip and retinal pigment epithelium layers whose mechanisms are unclear.
Shasha Gao, Yichao Li, David Bissig, Ethan D. Cohen, Robert H. Podolsky, Karen Lins Childers, Gregory Vernon, Sonia Chen, Bruce A. Berkowitz, Haohua Qian   +9 more
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Protocol to generate endothelial cells, pericytes, and fibroblasts in one differentiation round from human-induced pluripotent stem cells

STAR Protocols, 2023
Summary: Here, we present a protocol for differentiating human-induced pluripotent stem cells into three distinct mesodermal cell types: vascular endothelial cells (ECs), pericytes, and fibroblasts.
Tea Soon Park, Rishabh Hirday, Amir Ali, Roba Megersa, Rafael Villasmil, Eric Nguyen, Kapil Bharti   +6 more
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Applying next generation sequencing with microdroplet PCR to determine the disease-causing mutations in retinal dystrophies

BMC Ophthalmology, 2017
Background Inherited Retinal dystrophy (IRD) is a broad group of inherited retinal disorders with heterogeneous genotypes and phenotypes. Next generation sequencing (NGS) methods have been broadly applied for analyzing patients with IRD. Here we report a
Xinjing Wang, Wadih M. Zein, Leera D’Souza, Chimere Roberson, Keith Wetherby, Hong He, Angela Villarta, Amy Turriff, Kory R. Johnson, Yang C. Fann   +9 more
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Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation

Epigenetics & Chromatin, 2022
Background Methylation at cytosines (mCG) is a well-known regulator of gene expression, but its requirements for cellular differentiation have yet to be fully elucidated. A well-studied cellular differentiation model system is the eye lens, consisting of
Joshua Disatham, Lisa Brennan, Xiaodong Jiao, Zhiwei Ma, J. Fielding Hejtmancik, Marc Kantorow   +5 more
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Retinal Development and Pathophysiology in Kcnj13 Knockout Mice

Frontiers in Cell and Developmental Biology, 2022
Purpose: We constructed and characterized knockout and conditional knockout mice for KCNJ13, encoding the inwardly rectifying K+ channel of the Kir superfamily Kir7.1, mutations in which cause both Snowflake Vitreoretinal Degeneration (SVD) and Retinitis
Xiaodong Jiao, Zhiwei Ma, Jingqi Lei, Pinghu Liu, Xiaoyu Cai, Pawan K. Shahi, Chi-Chao Chan, Robert Fariss, Bikash R. Pattnaik, Lijin Dong, J. Fielding Hejtmancik   +10 more
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Retrospective analysis in oculocutaneous albinism patients for the 2.7 kb deletion in the OCA2 gene revealed a co-segregation of the controversial variant, p.R305W

Cell & Bioscience, 2017
Background Oculocutaneous albinism (OCA) is an autosomal recessive disorder. A significant portion of OCA patients has been found with a single pathogenic variant either in the TYR or the OCA2 gene.
Jackson Gao, Leera D’Souza, Keith Wetherby, Christian Antolik, Melissa Reeves, David R. Adams, Santa Tumminia, Xinjing Wang   +7 more
doaj   +1 more source