Results 11 to 20 of about 1,045,094 (185)

Bibliometric Analysis of Artificial Intelligence in Diabetic Retinopathy [PDF]

Zhongguo quanke yixue, 2023
Background In recent years, artificial intelligence (AI) has shown rapid development in the medical field, and its application in diabetic retinopathy (DR) has been expanding.
LIU Chun, JIAN Wenyuan, DUAN Junguo
doaj   +1 more source

Regulatory considerations for developing a phase I investigational new drug application for autologous induced pluripotent stem cells‐based therapy product

Stem Cells Translational Medicine, 2021
Induced pluripotent stem cells (iPSC)‐based therapies have been hailed as the future of regenerative medicine because of their potential to provide treatment options for most degenerative diseases. A key promise of iPSC‐based therapies is the possibility
Balendu Shekhar Jha, Mitra Farnoodian, Kapil Bharti   +2 more
doaj   +1 more source

Research Progress of Ocular Glymphatic System and Related Ocular Diseases [PDF]

Zhongguo quanke yixue, 2023
Recent discovered ocular glymphatic system, which is facilitated by aquaporin-4 (AQP4) and dependent on the exchange system of aqueous humor-tissue fluid in the perivascular space of retinal arterial and venous, ultimately acts as the role of expelling ...
ZHU Guangyu, CHENG Yuxin, LU Xuejing
doaj   +1 more source

Rod and Cone Coupling Modulates Photopic ERG Responses in the Mouse Retina

Frontiers in Cellular Neuroscience, 2020
Light adaptation changes both the sensitivity and maximum amplitude (Rmax) of the mouse photopic electroretinogram (ERG) b-wave. Using the ERG, we examined how modulation of gap junctional coupling between rod and cones alters the light-adapted ERG.
Yichao Li, Ethan D. Cohen, Haohua Qian
doaj   +1 more source

CLCC1 c. 75C>A Mutation in Pakistani Derived Retinitis Pigmentosa Families Likely Originated With a Single Founder Mutation 2,000–5,000 Years Ago

Frontiers in Genetics, 2022
Background: A CLCC1 c. 75C > A (p.D25E) mutation has been associated with autosomal recessive pigmentosa in patients in and from Pakistan. CLCC1 is ubiquitously expressed, and knockout models of this gene in zebrafish and mice are lethal in the ...
Yan Ma, Xun Wang, Xun Wang, Nadav Shoshany, Nadav Shoshany, Xiaodong Jiao, Adrian Lee, Gregory Ku, Emma L. Baple, Emma L. Baple, James Fasham, James Fasham, Raheela Nadeem, Muhammad Asif Naeem, Sheikh Riazuddin, Sheikh Riazuddin, S. Amer Riazuddin, Andrew H. Crosby, J. Fielding Hejtmancik   +18 more
doaj   +1 more source

Thalamic regulation of ocular dominance plasticity in adult visual cortex

eLife, 2023
Experience-dependent plasticity in the adult visual system is generally thought of as a cortical process. However, several recent studies have shown that perceptual learning or monocular deprivation can also induce plasticity in the adult dorsolateral ...
Yi Qin, Mehran Ahmadlou, Samuel Suhai, Paul Neering, Leander de Kraker, J Alexander Heimel, Christiaan N Levelt   +6 more
doaj   +1 more source

A novel LRAT mutation affecting splicing in a family with early onset retinitis pigmentosa

Human Genomics, 2018
Background and purpose Retinitis pigmentosa is an important cause of severe visual dysfunction. This study reports a novel splicing mutation in the lecithin retinol acyltransferase (LRAT) gene associated with early onset retinitis pigmentosa and ...
Yabin Chen, Li Huang, Xiaodong Jiao, Sheikh Riazuddin, S. Amer Riazuddin, J. Fielding Hetmancik   +5 more
doaj   +1 more source

The level of pediatric cataract in regions according to data of Ministry of Health of Ukraine for 2007-2016 years

Journal of Ophthalmology, 2017
The purpose of this study was to examine the changes in incidence and prevalence of cataract during the 10-year period between 2007-2016 among children who had been registered in the Health Care of Ukraine.
M. O. Chornobai
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Variants in NR6A1 cause a novel oculo vertebral renal syndrome

Nature Communications
Colobomatous microphthalmia is a potentially blinding congenital ocular malformation that can present either in isolation or together with other syndromic features. Despite a strong genetic component to disease, many cases lack a molecular diagnosis.
Uma M. Neelathi, Ehsan Ullah, Aman George, Mara I. Maftei, Elangovan Boobalan, Daniel Sanchez-Mendoza, Chloe Adams, David McGaughey, Yuri V. Sergeev, Ranya AI Rawi, Amelia Naik, Chelsea Bender, Irene H. Maumenee, Michel Michaelides, Tun Giap Tan, Siying Lin, Rafael Villasmil, Delphine Blain, Robert B. Hufnagel, Gavin Arno, Rodrigo M. Young, Bin Guan, Brian P. Brooks   +22 more
doaj   +1 more source