Results 51 to 60 of about 8,270,013 (310)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Functional imaging of the visual pathways [PDF]
Neurologic Clinics, 2003 Functional neuroimaging has provided a new view of activity in human visual cortex. There have been a series of interesting developments in understanding the relationship between the functional signals, particularly functional MRI, and basic measurements of action potentials and local field potentials.
Brian A, Wandell, Alex R, Wade
openaire +2 more sources
Visual function and the ageing visual system [PDF]
, 2014 The population is ageing. Globally, the number of older adults (aged 60 years or over) is expected to more than double, from 841 million people in 2013 to more than 2 billion in 2050.1 In light of the increasing size of the older adult population, there ...
McKendrick, Allison +3 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Individual differences in visual function
Experimental Eye Research, 2020 A significant proportion of research on the visual system focuses on general principles that apply to samples and/or populations. Many questions, however, are more suited to the specific characteristics of an individual. The visual system, like most systems of the body, is extremely variable with respect to function and susceptibility to disease ...
Billy R. Hammond, John Buch
openaire +2 more sources
Visual function in velocardiofacial syndrome [PDF]
Australian and New Zealand Journal of Ophthalmology, 1996 Velocardiofacial syndrome (VCFS) was first delineated in 1978 by Dr Robert Shprintzen' and is sometimes referred to as Shprintzen's syndrome. VCFS is an autosomal dominant disorder which is characterised by a pattern of similar congenital anomalies of variable expression: hypotonia, velopharyngeal insufficiency, hypernasal speech, developmental delay ...
L L, Kok +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
SLC16A8 is a causal contributor to age-related macular degeneration risk
npj Genomic MedicineAge-related macular degeneration (AMD), a complex neurodegenerative disease, is a leading cause of visual impairment worldwide with a strong genetic component.
Navid Nouri +23 more
doaj +1 more source
Visual Resources Outreach: Successes and Challenges in a New Role
, 2020 More than ever, visual resources are intrinsic to the teaching mission and visual literacy goals of universities. However, in many cases potential users are unaware of how libraries can assist in the implantation and integration of visual resources into ...
Kline, Heather
core