Results 81 to 90 of about 15,479,564 (391)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Functional visual fields: relationship of visual field areas to self‐reported function [PDF]

Ophthalmic and Physiological Optics, 2017
AbstractPurposeThe aim of this study is to relate areas of the visual field to functional difficulties to inform the development of a binocular visual field assessment that can reflect the functional consequences of visual field loss.MethodsFifty‐two participants with peripheral visual field loss undertook binocular assessment of visual fields using ...
Subhi, Hikmat, Latham, Keziah, Myint, Joy, Crossland, Michael   +3 more
openaire   +2 more sources

Decoding the activity of neuronal populations in macaque primary visual cortex [PDF]

, 2011
Visual function depends on the accuracy of signals carried by visual cortical neurons. Combining information across neurons should improve this accuracy because single neuron activity is variable.
Graf, Arnulf B. A., Jazayeri, Mehrdad, Kohn, Adam, Movshon, J. Anthony   +3 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Shortened Measurement Time of Functional Visual Acuity for Screening Visual Function

Journal of Ophthalmology, 2019
The functional visual acuity test which is the average of the visual acuities measured during a specific time frame (standard, 60 seconds) has been used recently to assess the visual function in various conditions. The availability of a shorter version of the functional visual acuity test promises to be patient friendly in that it is a simple screening
Yuki Hidaka, Sachiko Masui, Yasuyo Nishi, Masahiko Ayaki, Minako Kaido, Masaru Mimura, Kazuo Tsubota, Kazuno Negishi   +7 more
openaire   +3 more sources

SLC16A8 is a causal contributor to age-related macular degeneration risk

npj Genomic Medicine
Age-related macular degeneration (AMD), a complex neurodegenerative disease, is a leading cause of visual impairment worldwide with a strong genetic component.
Navid Nouri, Bailey Hannon Gussler, Amy Stockwell, Tom Truong, Gyeong Jin Kang, Kristen C. Browder, Yann Malato, Abdoulaye Sene, Sherri Van Everen, Charles C. Wykoff, David Brown, Arthur Fu, James D. Palmer, Jose Ronaldo Lima de Carvalho, Ehsan Ullah, Ranya Al Rawi, Emily Y. Chew, Wadih M. Zein, Bin Guan, Mark I. McCarthy, Jeffrey W. Hofmann, Shawnta Y. Chaney, Heinrich Jasper, Brian L. Yaspan   +23 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Differentiation of monocytes and polarized M1/M2 macrophages from human induced pluripotent stem cells

STAR Protocols
Summary: Here, we present a protocol to differentiate induced pluripotent stem cell (iPSC) into adherent hematopoietic progenitors that release floating CD14+ CD45+ monocytes into the culture medium.
Tea Soon Park, Rishabh Hirday, Russell Quinn, Sheela Panicker Jacob, Ricardo A. Feldman, Devika Bose, Ruchi Sharma, Kapil Bharti   +7 more
doaj   +1 more source

Effects of aging on optical quality and visual function

Clinical and experimental optometry, 2016
We assessed the effects of aging on visual function and optical quality in a healthy adult population and provide reference values for different age ranges.
Joan A Martínez-Roda, M. Vilaseca, Juan C. Ondategui, M. Aguirre, J. Pujol   +4 more
semanticscholar   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source