Results 151 to 160 of about 69,197,285 (240)

Quinoxaline–Triazole Hybrids: Exploring the Impact of Substituent Architecture on Cytotoxic Potency and Receptor Interaction

open access: yesChemistry &Biodiversity, Volume 23, Issue 11, November 2026.
A series of title compounds was synthesized, with 6e and 6k exhibiting the lowest IC50 values against MCF‐7, HeLa, and HepG2 cancer cell lines. Molecular docking and dynamics revealed strong binding to the adenosine A1 receptor (ΔG = –9.02 and –9.24 kcal/mol).
Bangar Reddy Vancha   +9 more
wiley   +1 more source

Isolation, Structural Elucidation, and Anti‐Melanogenic Activity of a Novel Pectic Polysaccharide From Alhagi camelorum Fisch

open access: yesChemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Polysaccharide extraction from Alhagi camelorum Fisch. was optimized, yielding ACP‐II‐1, a novel GalA‐rich, HG‐dominant pectin (26.145 kDa) containing branched RG‐I domains. ACP‐II‐1 reduced melanogenesis in forskolin‐stimulated B16F10 cells and a zebrafish model.
Zhitao Liu   +4 more
wiley   +1 more source

Productive or Transforming? How Epithelial Compartmentalization of HPV DNA and E6/E7 Transcripts Shapes Cervical Screening Assay Performance

open access: yesJournal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT The human papillomavirus (HPV) life cycle is linked to epithelial cell differentiation, with viral genome amplification, E6/E7 transcription, and virion assembly spatially compartmentalized within the cervical epithelium. This organization is disrupted in transforming lesions.
Konstanze Schichl, John Doorbar
wiley   +1 more source

Design of Lipopeptides and dsRNA‐Lipopeptide Complexes for Sprayable RNAi‐Based Plant Protection

open access: yesJournal of Peptide Science, Volume 32, Issue 11, November 2026.
Lipopeptide surfactants self‐assemble into nanostructure carriers that complex, protect, and deliver dsRNA, establishing structure–function relationships for next‐generation RNAi‐based insect control. ABSTRACT Broad‐spectrum insecticides persist in the environment, affecting non‐target organisms and selecting for resistant pest populations. In contrast,
Pascal Geisler   +3 more
wiley   +1 more source

Beyond monofunctionality: structural perspectives on phenol oxidase side activity in a catalase

open access: yesActa Crystallographica Section D, Volume 82, Issue 11, Page 1224-1239, November 2026.
Structural and biochemical characterization of the extracellular fungal catalase ClCPO uncovers an unexpected phenol oxidase promiscuity. Crystal structures, substrate docking and electron‐transfer pathway analysis identify ligand‐binding regions and support a working mechanistic model for catalase‐associated phenol oxidase activity.Catalases are ...
Christina Ferousi   +5 more
wiley   +1 more source

Inter- and intra-observer agreement in the assessment of the cervical transformation zone (TZ) by visual inspection with acetic acid (VIA) and its implications for a screen and treat approach: a reliability study. [PDF]

open access: yesBMC Womens Health, 2023
Benkortbi K   +10 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy