Results 61 to 70 of about 622,796 (261)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Interpretasi Visual dan Digital untuk Klasifikasi Tutupan Lahan di Kabupaten Kuningan, Jawa Barat

Jurnal Ilmu Pertanian Indonesia, 2019
Land cover information are needed to support decision making process on natural resource management. Remote sensing has been provideingr a huge distribution of geographical land cover information on various spatial scales.
Dede Kosasih, Muhammad Buce Saleh, Lilik Budi Prasetyo   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

UnionCAM: enhancing CNN interpretability through denoising, weighted fusion, and selective high-quality class activation mapping

Frontiers in Neurorobotics
Deep convolutional neural networks (CNNs) have achieved remarkable success in various computer vision tasks. However, the lack of interpretability in these models has raised concerns and hindered their widespread adoption in critical domains.
Hao Hu, Hao Hu, Rui Wang, Hao Lin, Huai Yu   +4 more
doaj   +1 more source

Agroforestry Systems of the Tehuacán-Cuicatlán Valley: Land Use for Biocultural Diversity Conservation

Land, 2019
The Tehuacán-Cuicatlán Valley, Mexico, is the semiarid region with the richest biodiversity of North America and was recently recognized as a UNESCO's World Heritage site.
Mariana Vallejo, M. Isabel Ramírez, Alejandro Reyes-González, Jairo G. López-Sánchez, Alejandro Casas   +4 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

An assessment of recent peat forest disturbances and their drivers in the Cuvette Centrale, Africa

Environmental Research Letters
The largest tropical peatland complex in the Cuvette Centrale is marked by persistent knowledge gaps. We assessed recent peat forest disturbances and their direct drivers from 2019 to 2021 in Cuvette Centrale, spanning the Republic of Congo (ROC) and the
Karimon Nesha, Martin Herold, Johannes Reiche, Robert N Masolele, Kristell Hergoualc’h, Erin Swails, Daniel Murdiyarso, Corneille E N Ewango   +7 more
doaj   +1 more source