Results 71 to 80 of about 622,796 (261)

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

User’s Interpretations of Features in Visualization

, 2015
Visualization is often used to identify features of interest in a dataset. The identification of features cannot be fully automated and the subjective interpretation of the user is involved in the identification of the feature. There can be many such interpretations, both from a single user as s/he explores the data, and also in collaborations ...
Aqeel Al-Naser, Masroor Rasheed, Duncan Irving, John M. Brooke   +3 more
openaire   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Interpreting Information Visualization

, 2021
Information visualization has become a prevailing part of our visual culture, a research field, and a line of work for designers. The literature on information visualization is diverse, dominated by handbooks aimed at designers and illustrated surveys, sometimes with an emphasis on historical examples.
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

基于人机交互目视解译的四川省稻城县古滑坡编目与其空间分布特征

Dizhen xuebao
四川省稻城县古滑坡数据库及其空间分布是研究该地区滑坡发生机理的重要基础，但该数据库目前仍然存在数据空白，制约了对该区域滑坡的深入研究。本文基于谷歌地球利用人机交互目视解译的方法对稻城县域的古滑坡进行了详细识别，共解译出1 324处滑坡，最大的滑坡面积达2.36 km2，最小面积约1 000 m2，滑坡总面积达306.78 km2。研究结果显示：① 稻城县古滑坡的规模主要以大型滑坡为主（占比66.39%），小型和中型滑坡数量较少（占比33.61%）；② 大部分古滑坡分布在河流两侧（占比58.61 ...
Zhiwen Xue, Chong Xu, Liye Feng, Huijuan Zhang, Jingjing Sun, Lei Li, Peng Wang, Jingyu Chen   +7 more
doaj   +1 more source

Unsupervised discovery of interpretable visual concepts

Information Sciences
Providing interpretability of deep-learning models to non-experts, while fundamental for a responsible real-world usage, is challenging. Attribution maps from xAI techniques, such as Integrated Gradients, are a typical example of a visualization technique containing a high level of information, but with difficult interpretation.
Mazini Rodrigues, Caroline, Boutry, Nicolas, Najman, Laurent   +2 more
openaire   +4 more sources

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source