Results 131 to 140 of about 695,432 (264)

Validity of low-contrast letter acuity as a visual performance outcome measure for multiple sclerosis. [PDF]

, 2017
Low-contrast letter acuity (LCLA) has emerged as the leading outcome measure to assess visual disability in multiple sclerosis (MS) research. As visual dysfunction is one of the most common manifestations of MS, sensitive visual outcome measures are ...
Nolan, R, Phillips, G, LaRocca, N, Kapoor, R, Hudson, L, Raynowska, J, Rudick, R, Balcer, LJ, Galetta, SL, Benedict, R, Multiple Sclerosis Outcome Assessments Consortium   +10 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Clinical characteristics and long-term visual outcome of severe phenotypes of chronic central serous chorioretinopathy

, 2018
Danial Mohabati,1,2 Thomas J van Rijssen,1 Elon HC van Dijk,1 Gregorius PM Luyten,1 Tom O Missotten,3 Carel B Hoyng,4 Suzanne Yzer,3 Camiel JF Boon1,5 1Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands; 2Department ...
Mohabati D, Boon CJF, Hoyng CB, Yzer S, van Dijk EHC, van Rijssen TJ, Luyten GPM, Missotten TO   +7 more
core  

Visual Outcome Of Traumatic Cataract Surgery In Ibadan, Nigeria

, 2009
To review the visual outcome of traumatic cataracts operated at the University College Hospital, Ibadanwith the view to making recommendations for improved outcome. All patients operated at the University College Hospital Ibadan, Nigeria between May 1999
Fasina, O, Bekibele, CO
core   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Predictive factors of visual outcome in acute post-cataract endophthalmitis

, 2009
International audiencePurpose: To study potential clinical and microbiological predictive factors of visual outcome in patients with acute endophthalmitis following cataract surgery.
Creuzot, Catherine, Bron, Alain M., Thuret, Gilles, Romanet, Jean-Paul, G THURET, M MAURIN, P DENIS, C CHIQUET, Combey de Lambert, Aurélie, A COMBEY‐DE LAMBERT, Cornut, Pierre-Loic, Denis, Philippe, C CREUZOT, Maurin, Max, Vandenesch, François, F VANDENESCH, Chiquet, Christophe, PL CORNUT, JP ROMANET, AM BRON   +19 more
core   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Visual processing, social cognition and functional outcome in schizophrenia

, 2010
Visual processing deficits are well recognised in schizophrenia and have potentially important clinical implications. First, the pattern of deficits for different visual tasks may help understand the underlying pathophysiology of the visual dysfunction ...
Surguladze, Simon, Ffytche, Dominic H., McKendrick, Allison, Brittain, Philip   +3 more
core   +1 more source