Results 91 to 100 of about 757,076 (313)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The role of feedback in visual masking and visual processing

Advances in Cognitive Psychology, 2007
This paper reviews the potential role of feedback in visual masking, for and against. Our analysis reveals constraints for feedback mecha- nisms that limit their potential role in visual masking, and in all other general brain functions. We propose a feedforward model of visual masking, and provide a hypothesis to explain the role of feedback in visual
Macknik, Stephen L., Martinez-Conde, Susana   +1 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Reliability of neural coding on different stages of visual information processing in an insect brain

, 2006
Grewe J. Reliability of neural coding on different stages of visual information processing in an insect brain. Bielefeld (Germany): Bielefeld University; 2006.Humans as well as animals react to environmental changes by adjusting their behaviour.
Grewe, Jan
core  

An Enhanced Visualization Process Model for Incremental Visualization

IEEE Transactions on Visualization and Computer Graphics, 2016
With today's technical possibilities, a stable visualization scenario can no longer be assumed as a matter of course, as underlying data and targeted display setup are much more in flux than in traditional scenarios. Incremental visualization approaches are a means to address this challenge, as they permit the user to interact with, steer, and change ...
Hans-Jörg Schulz, Marco Angelini, Giuseppe Santucci, Heidrun Schumann   +3 more
openaire   +2 more sources

Modeling Spectral LED Degradation Using an Unsupervised Machine Learning Approach

IEEE Access
The modeling of spectral characteristics of light-emitting diodes (LED) has been addressed in various studies. We extend the current state of knowledge by modeling the spectral characteristics of commercially available high-power LEDs, exhibiting a ...
Alexander Herzog, Benoit Hamon, Paul Myland, Peter Foerster, Simon Benkner, Babak Zandi, Victor Guerra, Sebastian Schoeps, Willem D. van Driel, Tran Quoc Khanh   +9 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Neural Network Model for Detection of Edges Defined by Image Dynamics

Frontiers in Computational Neuroscience, 2019
Insects can detect the presence of discrete objects in their visual fields based on a range of differences in spatiotemporal characteristics between the images of object and background. This includes but is not limited to relative motion.
Patrick A. Shoemaker
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source