Results 21 to 30 of about 396,544 (263)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Delayed inhibition of an anticipatory action during motion extrapolation [PDF]

, 2010
Background: Continuous visual information is important for movement initiation in a variety of motor tasks. However, even in the absence of visual information people are able to initiate their responses by using motion extrapolation processes ...
Welber Marinovic, Tresilian, James R., Tresilian, James, Marinovic Welber, Stephan Riek, James R Tresilian, Riek Stephan, Reid, Campbell S., Annaliese M Plooy, Plooy, Annaliese M., Reid Campbell S, Campbell S Reid, Marinovic, Welber, Tresilian James R, Riek, Stephan, Plooy Annaliese M   +15 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Effects of noise on visual orienting [PDF]

, 1987
Eleven experiments are reported which examine the effects of 90 dB (A) white noise on the processes which govern orienting of attention in visual space. The selectivity hypothesis argues that noise alters the priorities which govern stimulus selection so
Spencer, Martin Bramwell Howard
core  

Multisensory Information Facilitates Reaction Speed by Enlarging Activity Difference between Superior Colliculus Hemispheres in Rats

, 2011
Animals can make faster behavioral responses to multisensory stimuli than to unisensory stimuli. The superior colliculus (SC), which receives multiple inputs from different sensory modalities, is considered to be involved in the initiation of motor ...
Miquel Bosch, Yoshio Sakurai, Sakata Shuzo, Sakurai Yoshio, Sadakane Osamu, Hirokawa, Junya, Sadakane, Osamu, Sakata, Shuzo, Yamamori, Tetsuo, Hirokawa, J., Sakata, S., Sakurai, Yoshio, Tetsuo Yamamori, Yamamori Tetsuo, Sadakane, O., Bosch Miquel, Junya Hirokawa, Osamu Sadakane, Yamamori, T., Hirokawa Junya, Bosch, M., Sakurai, Y., Bosch, Miquel, Shuzo Sakata   +23 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Decision time, slow inhibition, and theta rhythm [PDF]

, 2010
In this paper, we examine decision making in a spiking neuronal network and show that longer time constants for the inhibitory neurons can decrease the reaction times and produce theta rhythm.We analyze the mechanism and find that the spontaneous firing
Smerieri, Anteo, Edmund T. Rolls, Feng, Jianfeng, Jianfeng Feng, Rolls, Edmund T., Anteo Smerieri   +5 more
core   +1 more source