Results 41 to 50 of about 396,544 (263)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Visual attention with implications for unilateral spatial neglect. [PDF]

, 1992
Recent models of visual attention (eg. Rizzolatti et al., 1987) have suggested that a similar system orients visual attention as is used to produce a saccadic eye movement. This thesis provides further support for the link between the attentional and eye
Walker, R, Walker, Robin
core  

Alpha-band rhythms in visual task performance: phase-locking by rhythmic sensory stimulation [PDF]

, 2012
Oscillations are an important aspect of neuronal activity. Interestingly, oscillatory patterns are also observed in behaviour, such as in visual performance measures after the presentation of a brief sensory event in the visual or another modality. These
Gregor Thut, Paterson Gavin, Gavin Paterson, Gross, J., de Graaf Tom A., Thut Gregor, Gross, Joachim, Gross Joachim, Rusch Tessa, Er T. Sack, Graaf, Tom A. de, Rusch, T., Paterson, Gavin, Alexander T Sack, Thut, G., Thut, Gregor, Sack, Alexander T., Paterson, G., Tom A de Graaf, Sack Alexander T., Sack, A.T.; id_orcid, de Graaf, T.A., Sack, A.T., Joachim Gross, Tom A. De Graaf, Tessa Rusch, Rusch, Tessa   +26 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Atividade física e tempo de reação de mulheres idosas [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Desportos. Programa de Pós-Graduação em Educação FísicaEste estudo teve como objetivo verificar a relação entre a atividade física e o tempo de reação de mulheres idosas ...
Binotto, Maria Angélica
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Reaction time on fencing and karate high level athletes

, 2008
The great speed of the actions in combat sports makes very difficult to react quickJy without mistakes. If the fighter had longer time to react, their reaction would be more accurate.
Sillero Quintana, Manuel, López Adán, Enrique, Saucedo Morales, Francisco, Martínez de Quel Pérez, Óscar   +3 more
core  

Visual hemispatial neglect, re-assessed [PDF]

, 2008
Increased computer use in clinical settings offers an opportunity to develop new neuropsychological tests that exploit the control computers have over stimulus dimensions and timing.
List, Alexandra, Esterman, Michael, Vanvleet, Thomas M., Robertson, Lynn C., Stanton, Victoria, Brooks, Joseph L, Landau, Ayelet N., Bowman, G., Flevaris, Anastasia V., Schendel, Krista   +9 more
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source