Results 51 to 60 of about 1,224,970 (257)

Visual features of cartographic representation in map perception

Polish Cartographical Review, 2016
The author describes the properties and mechanisms of visual perception in the context of their significance to the principles of symbol design as used in cartography. Map perception relies on the process of visual perception. Therefore, the knowledge of
Żyszkowska Wiesława
doaj   +1 more source

Learning prediction error neurons in a canonical interneuron circuit

eLife, 2020
Sensory systems constantly compare external sensory information with internally generated predictions. While neural hallmarks of prediction errors have been found throughout the brain, the circuit-level mechanisms that underlie their computation are ...
Loreen Hertäg, Henning Sprekeler
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

AFCLNet: An Attention and Feature-Consistency-Loss-Based Multi-Task Learning Network for Affective Matching Prediction in Music–Video Clips

Sensors
Emotion matching prediction between music and video segments is essential for intelligent mobile sensing systems, where multimodal affective cues collected from smart devices must be jointly analyzed for context-aware media understanding.
Zhibin Su, Jinyu Liu, Luyue Zhang, Yiming Feng, Hui Ren   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The role of visual load in the process of children’s and teenagers’ visual system formation

Journal of Ophthalmology, 2015
The aim of the research is the analysis of text visual load influence on the structural and functional state of children’s and teenagers’ visual system. 97 children and teenagers as well as 88 young adults took part in the research. Materials and
M. L. Kochina, A. V. Yavorsky, A. S. Evtushenko   +2 more
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Abnormal Connectivity and Brain Structure in Patients With Visual Snow

Frontiers in Human Neuroscience, 2020
ObjectiveVisual snow (VS) is a distressing, life-impacting condition with persistent visual phenomena. VS patients show cerebral hypermetabolism within the visual cortex, resulting in altered neuronal excitability.
Njoud Aldusary, Njoud Aldusary, Ghislaine L. Traber, Ghislaine L. Traber, Ghislaine L. Traber, Patrick Freund, Patrick Freund, Patrick Freund, Fabienne C. Fierz, Konrad P. Weber, Konrad P. Weber, Arwa Baeshen, Arwa Baeshen, Jamaan Alghamdi, Bujar Saliju, Shila Pazahr, Reza Mazloum, Reza Mazloum, Fahad Alshehri, Fahad Alshehri, Klara Landau, Spyros Kollias, Marco Piccirelli, Lars Michels   +23 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source