Results 61 to 70 of about 1,694,754 (343)

Neural network analysis of the visual system functional transformation in normal aging

open access: yesОфтальмохирургия, 2022
Purpose. To reveal functional transformation patterns of the visual system in normal aging using neural network analysis. Material and methods. We examined 170 people aged 18 to 60 with objective refraction (under conditions of cycloplegia) from +5.5 D ...
O.I. Rozanova, I.M. Mikhalevich
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

open access: yesFEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke   +2 more
wiley   +1 more source

Functional Integration of Newborn Neurons in the Zebrafish Optic Tectum

open access: yesFrontiers in Cell and Developmental Biology, 2019
Neurogenesis persists during adulthood in restricted parts of the vertebrate brain. In the optic tectum (OT) of the zebrafish larva, newborn neurons are continuously added and contribute to visual information processing.
Jonathan Boulanger-Weill, Germán Sumbre
doaj   +1 more source

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

open access: yesFEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon   +5 more
wiley   +1 more source

Distribution of AMPA-type glutamate receptor subunits in the chick visual system

open access: yesBrazilian Journal of Medical and Biological Research, 1997
Several glutamate receptor (GluR) subunits have been characterized during the past few years. In the present study, subunit-specific antisera were used to determine the distribution of the AMPA-type glutamate receptor subunits GluR1-4 in retinorecipient ...
R.S. Pires, L.R.G. Britto
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Age- and Wavelength-Dependency of Drosophila Larval Phototaxis and Behavioral Responses to Natural Lighting Conditions

open access: yesFrontiers in Behavioral Neuroscience, 2017
Animals use various environmental cues as key determinant for their behavioral decisions. Visual systems are hereby responsible to translate light-dependent stimuli into neuronal encoded information.
Simon G. Sprecher, Tim-Henning Humberg
doaj   +1 more source

Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system

open access: yeseLife, 2020
Although the primate visual system has been extensively studied, detailed spatial organization of white matter fiber tracts carrying visual information between areas has not been fully established.
Hiromasa Takemura   +6 more
doaj   +1 more source

A Spatial-Constraint Model for Manipulating Static Visualizations [PDF]

open access: yesarXiv, 2023
We propose a spatial-constraint approach for modeling spatial-based interactions and enabling interactive visualizations, which involves the manipulation of visualizations through selection, filtering, navigation, arrangement, and aggregation. We proposes a system that activates static visualizations by adding intelligent interactions, which is ...
arxiv  

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

open access: yesMolecular Oncology, Volume 19, Issue 5, Page 1386-1403, May 2025.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale   +9 more
wiley   +1 more source

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