Results 121 to 130 of about 4,045,707 (379)

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Impact of MRI radiomic feature normalization for prognostic modelling in uterine endometrial and cervical cancers

open access: yesScientific Reports
Widespread clinical use of MRI radiomic tumor profiling for prognostication and treatment planning in cancers faces major obstacles due to limitations in standardization of radiomic features.
Erlend Hodneland   +8 more
doaj   +1 more source

A Machine Learning-Based Pipeline for the Extraction of Insights from Customer Reviews

open access: yesBig Data and Cognitive Computing
The efficiency of natural language processing has improved dramatically with the advent of machine learning models, particularly neural network-based solutions. However, some tasks are still challenging, especially when considering specific domains. This
Róbert Lakatos   +7 more
doaj   +1 more source

The Network Data Repository with Interactive Graph Analytics and Visualization

open access: yesAAAI Conference on Artificial Intelligence, 2015
NetworkRepository (NR) is the first interactive data repository with a web-based platform for visual interactive analytics. Unlike other data repositories (e.g., UCI ML Data Repository, and SNAP), the network data repository (networkrepository.com ...
Ryan A. Rossi, Nesreen Ahmed
semanticscholar   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Fully automatic wound segmentation with deep convolutional neural networks

open access: yesScientific Reports, 2020
Acute and chronic wounds have varying etiologies and are an economic burden to healthcare systems around the world. The advanced wound care market is expected to exceed $22 billion by 2024.
Chuanbo Wang   +7 more
doaj   +1 more source

Visual Imagery: Visual Format or Visual Content? [PDF]

open access: yesMind & Language, 2010
It is clear that visual imagery is somehow significantly visual. Some theorists, like Kosslyn, claim that the visual nature of visualisations derives from features of the neural processes which underlie those episodes. Pylyshyn claims, however, that it may merely reflect special features of the contents which we grasp when we visualise things.
openaire   +2 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Diffraction Efficiency Enhanced Volume Holographic Gratings via Coupling Ag Thin Film

open access: yesIEEE Photonics Journal, 2019
Volume holographic gratings (VHGs) act as an in-coupler or out-coupler could be applied in holographic waveguide display system in which high diffraction efficiency is one of the key factors.
Yunping Qiu   +5 more
doaj   +1 more source

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