Results 161 to 170 of about 3,371,601 (332)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Visualizing dynamics of charges and strings in (2 + 1)D lattice gauge theories [PDF]

Tyler A. Cochran, B. Jobst, Eliott Rosenberg, Y. D. Lensky, Gaurav Gyawali, Norhan M. Eassa, Melissa Will, Aaron Szasz, Dmitry A. Abanin, Rajeev Acharya, Laleh Aghababaie Beni, Trond I. Andersen, M. Ansmann, Frank Arute, Kunal Arya, Abraham Asfaw, Juan Atalaya, Ryan Babbush, B. Ballard, Joseph C. Bardin, Andreas Bengtsson, Alexander Bilmes, Alexandre Bourassa, Jenna Bovaird, Michael Broughton, D. A. Browne, Brett Buchea, B. B. Buckley, T. Burger, Brian Burkett, Nicholas Bushnell, A. Cabrera, J Campero, Hung-Shen Chang, Z. Chen, Benjamin Chiaro, Jahan Claes, Agnetta Y. Cleland, J. Cogan, Roberto Collins, P. Conner, William Courtney, A. L. Crook, Ben Curtin, Sayan Das, Sean Demura, Luis Lorenzo, Agustín Di Paolo, Paul Donohoe, Ilya Drozdov, A. Dunsworth, Alec Eickbusch, Aviv Moshe Elbag, Mahmoud Elzouka, C. Erickson, V. S. Ferreira, Leslie Flores Burgos, Ebrahim Forati, A. G. Fowler, Brooks Foxen, Suhas Ganjam, Rebeca Gasca, Élie Genois, W. Giang, D. Gilboa, Raja Gosula, Alejandro Grajales Dau, Dietrich Graumann, Alex Greene, Jonathan A. Gross, Steve Habegger, M. Hansen, Matthew P. Harrigan, Sean D. Harrington, Paula Heu, Oscar Higgott, J. Hilton, Hanxia Huang, Ashley Huff, William J. Huggins, E. Jeffrey, Jiang Zhang, C. Jones, Chaitanya Joshi, Pavol Juhás, Dvir Kafri, Hyunsun Kang, Amir H. Karamlou, Kostyantyn Kechedzhi, Trupti Khaire, Tanuj Khattar, Mostafa Khezri, Seon Kim, Paul V. Klimov, Bryce Kobrin, Alexander N. Korotkov, Fedor Kostritsa, John Mark Kreikebaum, Vladislav D. Kurilovich, David Landhuis   +99 more
openalex   +1 more source

A THREE-DIMENSIONAL SIMULATION AND VISUALIZATION SYSTEM FOR UAV PHOTOGRAMMETRY [PDF]

, 2017
Yubin Liang, Yanyun Qu, Tiejun Cui
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Visualizing Vehicle Acceleration and Braking Energy at Intersections along a Major Traffic Corridor

, 2021
Haowen Xu, Andy Berres, Chieh Ross Wang, Tim J. LaClair, Jibonananda Sanyal   +4 more
openalex   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Self-Recognition in Data Visualization: How People See Themselves in Social Visualizations [PDF]

Self-recognition is an intimate act performed by people. Inspired by Paul Ricoeur, we reflect upon the action of self-recognition, especially when data visualization represents the observer itself.
Cellard, Loup, Rodighiero, Dario
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Visualizing Acoustic Space [PDF]

, 2008
Gascia Ouzounian
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source