Results 181 to 190 of about 1,896,602 (219)

First-Trimester Assessment of the Extended Fetal Cardiovascular System Using the CASSEAL 3 × 3 Framework: Feasibility, Reproducibility and Diagnostic Performance. [PDF]

J Cardiovasc Dev Dis
Martínez Payo C, García Nieto I, Martínez AJS, Salas Gil C, Álvarez Martín T, Gambacorti Z, Pintado Recarte P, Pena-Burgos EM, Ortega MA, De León-Luis J, Bravo Arribas C.   +10 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Sustainable Au (III) adsorption using greenly Fe-BTC/PpPDA synthesized composite: kinetic and isothermal studies. [PDF]

R Soc Open Sci
Somda W, Konate FO, Koffi KR, Sanou GY, Lingane R, Bombiri IN, Khalid M, Yonli AH.   +7 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Interpreting Lumbar Compensation in Severe Adolescent Idiopathic Scoliosis. [PDF]

Global Spine J
Yılmaz E, Özer NK, Topal E.
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Efficacy of plasma exchange and exchange transfusion in the clinical management of severe hypertriglyceridemia in emergency. [PDF]

Mol Genet Metab Rep
Stefanutti C, Zeppa G, Perrone G, Labbadia G, Galoppi P, Demarco V, Fornari E, Bordugo A, Santelia C, Mancioppi V, Zenti MG, Cossu M, Sovrano B, Vivenzio A, Cohen H, Soran H, Pisciotta L, Maffeis C, Bjelakovic B, Widhalm K, Rizzo G, MIGHTY MEDIC - Multidisciplinary International Group for Hemapheresis Therapy and Metabolic Disorders Control.   +21 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source