Results 161 to 170 of about 1,896,602 (219)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Bridging trust and performance in intelligent systems: Hybrid explainable AI approaches for interpreting large language models. [PDF]

PLoS One
P AS, P TS.
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Developing sustainable emergency care systems in sub-saharan africa: milestones and lessons from 15 years of clinical and educational initiatives in Tanzania. [PDF]

Afr J Emerg Med
Sawe HR, Kilindimo SS, Mapunda EG, Hyuha G, Medarakini H, Simbila AN, Biita M, Sylvanus E, Kiremeji M, Shaaban SY, Obogo M, Sakita FM, Mussa RY, Sirili N, Mfinanga JA.   +14 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Second ipsilateral locoregional recurrence in patients with hormone receptor-positive, HER2-negative breast cancer: a cohort study. [PDF]

EClinicalMedicine
Milano M, Valenza C, Bianco N, Manacorda S, Cavallone M, Matera L, Marsicano RM, Battaiotto E, Berton Giachetti PPM, Giordano E, Etessami JD, Trapani D, Schena S, Sangalli C, Kahler Ribeiro Fontana S, Gandini S, Veronesi P, Galimberti V, Colleoni M, Curigliano G, Munzone E.   +20 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Small-caliber cap-assisted identification of an exposed vessel and direct clipping for colonic diverticular bleeding. [PDF]

Endoscopy
Doba N, Someya M, Goto K, Yonamine R, Abe S, Maeda S.   +5 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Performance of Transvaginal First-Trimester Anatomical Screening by Operators with Different Levels of Experience: A Randomized Controlled Trial. [PDF]

Diagnostics (Basel)
Leesukon P, Dulyaphat W, Moradokkasem W, Lertrat W, Diawtipsukon S, Chansriniyom N, Tongsong T, Tangshewinsirikul C.   +7 more
europepmc   +1 more source