Results 131 to 140 of about 1,755,266 (312)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Interactive Hierarchical Data Investigation using Abstractions -- the Waltz Visualization Environment [PDF]
, 1996 Scientific visualization is becoming common in the work-place; hastened by the growth in the power of computers generating data that needs to be visualized.
Roberts, Jonathan C.
core
The Unique Immune System of Bats: An Evolutionary Analysis and Bibliometric Study
Ecology and EvolutionBats exhibit a greater capacity to tolerate diverse viruses than other terrestrial mammals. To address these questions, we utilized evolutionary and bibliometric analyses to explore the immunological characteristics of bats and identify contemporary ...
Rui Li +4 more
doaj +1 more source
Frontiers in Plant ScienceSoil organic carbon is a vital component of the soil carbon pool. Investigation of its composition and dynamics is crucial for enhancing carbon sequestration in soils and for stabilizing the global carbon cycle. In recent years, considerable research has
Guolong Ge +15 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Parameter sensitivity visualization for DTI fiber tracking
, 2009 Fiber tracking of Diffusion Tensor Imaging (DTI) data offers a unique insight into the three-dimensional organisation of white matter structures in the living brain.
Haar Romeny, BM Bart ter +7 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Hardware-accelerated interactive data visualization for neuroscience in Python.
, 2013 Large datasets are becoming more and more common in science, particularly in neuroscience where experimental techniques are rapidly evolving. Obtaining interpretable results from raw data can sometimes be done automatically; however, there are numerous ...
Kenneth D Harris +5 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source