Results 81 to 90 of about 1,563,996 (294)

Visualization of International Energy Policy Research

Energies, 2016
The complexity of policy decision making is well recognized. It is not clear, however, what role academic policy research has played in influencing the directions of policy outcomes and how the research has intertwined with notable issues globally. Given
Xiaoling Wang, Jatin Nathwani, Chunyou Wu   +2 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

An in-depth analysis of research on posthepatectomy liver failure (2006-2024): exploring trends and future directions through a bibliometric approach

Frontiers in Medicine
ObjectiveThis study aims to identify global hotspots and future trends within the research on posthepatectomy liver failure (PHLF).DesignBibliometric analysis through science mapping and performance analysis.Data sourcesThe Web of Science Core Collection.
Yachen Wu, Jiangtao Li, Zhaohai Liu, Mengliang Jiang, Hao Liang, Sajid Ameer, Xilin Qu, Zhangtao Long, Zhu Zhu, Xiaoming Dai   +9 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Bibliometric Analysis of Classroom Engagement: A Review Based on Web of Science Database

Behavioral Sciences
Classroom engagement, a critical factor in enhancing learning outcomes and personal development, serves as a direct manifestation of students’ agency in learning.
Zhen Zhang, Yali Zhao, Xiaoyu Huang, Chunhui Qi, Guoxiang Zhao   +4 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Research hotspots and emerging trends in MicroRNA therapy for neuropathic pain: a bibliometric analysis (2009–2024)

Frontiers in Molecular Neuroscience
ObjectiveThis study systematically investigates the evolving trends, research hotspots, and future directions in microRNA-based therapy for neuropathic pain (NP) through bibliometric analysis.MethodsWe extracted literature related to microRNA ...
Yiqiang Zhang, Shushu Chen, Jiangtao Chi, Qinghua Gao, Yujie Li, Huaizhao Wang, Yuanyuan Yu   +6 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Research trends in post-stroke aphasia (2004–2024): a bibliometric and visualized analysis

Frontiers in Neurology
IntroductionThis study employs bibliometric analysis to systematically investigate the evolutionary trajectory and disciplinary dynamics of post-stroke aphasia mechanism research from 2004 to 2024.MethodsThrough multidimensional examination of 3,492 ...
Yufeng Peng, Kewei Peng, Yunfeng Ying, Luyao Li   +3 more
doaj   +1 more source