Results 51 to 60 of about 491,563 (259)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Nordic walking as a physical education discipline for students of special medical groups [PDF]

Физическое воспитание и студенческий спорт
This paper analyzes the implementation of Nordic walking in the physical education curriculum for students of a special medical group at Pavlov First Saint Petersburg State Medical University. The study presents a comparative assessment of students’
Guseva, Olga A., Podgaiko, Olga B., Andreeva, Svetlana V.   +2 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Use of the forced-oscillation technique to estimate spirometry values

International Journal of COPD, 2017
Shoichiro Yamamoto,1 Seigo Miyoshi,1 Hitoshi Katayama,1 Mikio Okazaki,2 Hisayuki Shigematsu,2 Yoshifumi Sano,2 Minoru Matsubara,3 Naohiko Hamaguchi,1 Takafumi Okura,1 Jitsuo Higaki1 1Department of Cardiology, Pulmonology, Hypertension, and Nephrology ...
Yamamoto S, Miyoshi S, Katayama H, Okazaki M, Shigematsu H, Sano Y, Matsubara M, Hamaguchi N, Okura T, Higaki J   +9 more
doaj  

Prediction of Spirometric Indices Using Forced Oscillometric Indices in Patients with Asthma, COPD, and Interstitial Lung Disease

International Journal of COPD, 2020
Seigo Miyoshi,1 Hitoshi Katayama,1 Minoru Matsubara,2 Takahide Kato,1 Naohiko Hamaguchi,1 Osamu Yamaguchi1 1Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan ...
Miyoshi S, Katayama H, Matsubara M, Kato T, Hamaguchi N, Yamaguchi O   +5 more
doaj  

Impact of asymptomatic idiopathic scoliosis on pulmonary function

National Journal of Physiology, Pharmacy and Pharmacology, 2013
Background: Scoliosis is considered as one of the commonest spinal deformity to affect the pulmonary functions because of its ability to alter the respiratory mechanics.
Ningappa S Muniyappanavar, Shivakumar J, Prakash D Dixit, Jnaneshwara P Shenoy, Shivayogappa S Teli, Chandrashekar A K   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Supervised Tele-rehabilitation versus Unsupervised Home-based Pulmonary Rehabilitation in Individuals with COPD: A Randomised Controlled Trial Protocol [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a major global health concern characterised by irreversible airflow limitation due to airway and alveolar abnormalities.
Ridhi Vatsa, Akanksha Saxena, Mandeep Kumar Jangra , Sameer Singhal   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source