Results 51 to 60 of about 528,981 (304)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Evaluation of Respiratory Capacity of Pottery and Ceramic Workers in Lalejin-Hamadan

open access: yesپزشکی بالینی ابن سینا, 1999
For  evaluation  of respiratory capacities, the amount of VC(Vital Capacity),    FVC (Forced Vital Capacity), FEV (Forced Expiratory Volume in one second)        were   measured   in   221   pottery,   ceramic,   slip,  molder workers in Lalejin ...
Abdolrahman Bahrami, Hosein Mahjub
doaj  

VITAL CAPACITY OF THE LUNGS OF TRAMPOLINE GYMNASTS AGED 10-13

open access: yesScience of Gymnastics Journal
Vital capacity (VC) tests are an important tool in assessing the functioning of the respiratory system. Low levels of vital capacity can indicate health problems such as asthma, chronic obstructive pulmonary disease, and other respiratory conditions ...
Bartłomiej Patryk Hes   +1 more
doaj   +1 more source

The correlation of vital capacity readings and clinical examination: with special reference to vital capacity observations in obese subjects [PDF]

open access: yes, 1930
After taking many hundreds of observations of vital lung capacity, the following conclusions are arrived at :-(1) Individual variations present one of the greatest drawbacks to the value of vital capacity readings.It is necessary to know the ...
Rolt, John B.
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Maximum phonation times and vital capacity in dysphonic women

open access: yes, 2018
Objective: to verify the correlation between vital capacity and maximum phonation times of /ė/ (unvoiced) and /s/, as well as compare and relate them with the professional voice use and age in women with functional or organic-functional dysphonia ...
Carla Aparecida Cielo (5910803)   +3 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Difference between slow vital capacity and forced vital capacity in the diagnosis of airflow limitation [PDF]

open access: yesJornal Brasileiro de Pneumologia, 2020
Carlos Alberto de Castro Pereira   +6 more
doaj   +3 more sources

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

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