Results 41 to 50 of about 1,254 (258)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Planetary Melodrama and Tin Extraction

Ecokritike
This essay departs from anthropocentric and deconstructive readings of The Tin Mine (2005) by Jira Maligool, adapted from Ajin Panjapan’s autobiographical short stories, and reframes it as a planetary melodrama.
Paweenwat Thongprasop
doaj   +1 more source

How much do we need – What is the limitation of wants and where do we end up with unfulfilled desires?

International Journal of Science Annals, 2023
Background and Aim of Study: The paper considers the significance of recognizing the limitations of our wants and the consequences of unfulfilled desires.
M. P. Bhandari
doaj   +1 more source

Relational Encounters and Vital Materiality in the Practice of Craft Work [PDF]

Organization Studies, 2019
Practice-based studies of organization have drawn attention to the importance of the body as a site of knowledge and knowing. However, relational encounters between bodies and objects, and the affects they generate, are less well understood in organization studies.
Emma Bell, Sheena J. Vachhani
openaire   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A Vital Challenge to Materialism

Philosophy, 2016
AbstractLife poses a threat to materialism. To understand the phenomena of animate nature, we make use of a teleological form of explanation that is peculiar to biology, of explanations in terms of what I call the ‘vital categories’ – and this holds even for accounts of underlying physico-chemical ‘mechanisms’.
openaire   +3 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

SEXUALITY IN A CONTEXT OF SPECULATIVE POSTHUMANISM: HUMAN-POSTHUMAN RUPTURES AND DISCONNECTIONS

Вісник Харківського національного університету імені В.Н. Каразіна. Серія Філософія, філософські перипетії, 2019
In this article human-posthuman ruptures and disconnections both in comprehension and in practices, as well as the possibility of epistemological contingency contemporaneously are investigated.
Nataliia V. Zahurska
doaj   +1 more source

Vital Materialism and the Problem of Ethics in the Radical Enlightenment [PDF]

Philosophica, 2013
From Hegel to Engels, Sartre and Ruyer (Ruyer, Revue Philosophique 116(7–8):28–49, 1933), to name only a few, materialism is viewed as a necropolis, or the metaphysics befitting such an abode; many speak of matter’s crudeness, bruteness, coldness or stupidity.
openaire   +2 more sources