Results 61 to 70 of about 515,545 (281)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Building the Global Sisterhood: Measurement, Evaluation and Learning Report for the Conrad N. Hilton Foundation's Catholic Sisters Initiative Strategy [PDF]

, 2015
The Conrad N. Hilton Foundation Catholic Sisters Initiative launched a five-year strategy in February 2013 to enhance the vitality of Catholic sisters, who in turn advance human development around the globe. The Sisters Initiative aims to support efforts

core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Testamentos vitales [PDF]

Persona y Derecho, 1970
El Testamento vital, término convencional que recogemos pese a no ser aceptado en la legislación española, aspira a mantener la ilusión de control autónomo sobre la gestión de la enfermedad. A su vez, el testamento vital eutanásico aparece como el argumento que permitiría vincular autonomía con aceptación del homicidio eutanásico.
Serrano, J.M. (José Miguel), Serrano, J.M. (José Miguel)   +1 more
openaire   +3 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

QUESTIONING JAVANESE LANGUAGE VALUE AND VITALITY WITH ITS MILLIONS OF SPEAKERS [PDF]

, 2017
Javanese holds the top rank of local language used in Indonesia for its biggest speakers noted. When many may worry about language endangerment, Javanese may not be one of them. Its high percentage usage makes people believe that this language is ‘safe’
Susilowati, Dwi
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

‘This is the core of what we do’: a qualitative study of social prescribers’ attitudes towards spiritual health training and their future training needs

BMC Primary Care
Background Despite the evidence supporting the importance of spiritual health to people’s wellbeing across diverse fields of treatment, the topic of spiritual health is not currently mentioned in National Health Service (NHS) training materials for ...
Mark Adley, Alexandra Thompson, Philip Mordue, Amy O’Donnell, Barbara Hanratty, Ishbel Orla Whitehead   +5 more
doaj   +1 more source

Feasibility of a home-based interdisciplinary rehabilitation program for patients with Post-Intensive Care Syndrome: the REACH study

Critical Care, 2021
Background Survivors of critical illness experience long-term functional challenges, which are complex, heterogeneous, and multifactorial in nature. Although the importance of rehabilitation interventions after intensive care unit (ICU) discharge is ...
Mel E. Major, Daniela Dettling-Ihnenfeldt, Stephan P. J. Ramaekers, Raoul H. H. Engelbert, Marike van der Schaaf   +4 more
doaj   +1 more source

Study on the Classification Method of Urban Vitality Spatial Pattern Based on Full-Time Vitality Spectrum:A Case Study of Tianjin, China [PDF]

, 2020
Urban vitality represents the use of urban space. The higher the vitality, the stronger the attraction. How urban space is used in the planning process and how the vitality changes within the space during the day are important evaluation
Gao, Ziwei, Sun, Zongyao, Zeng, Peng
core