Results 81 to 90 of about 189,973 (301)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hippocampal capillary pericytes in post-stroke and vascular dementias and Alzheimer’s disease and experimental chronic cerebral hypoperfusion

Acta Neuropathologica Communications
Neurovascular unit mural cells called ‘pericytes’ maintain the blood-brain barrier and local cerebral blood flow. Pathological changes in the hippocampus predispose to cognitive impairment and dementia.
Yoshiki Hase, Dan Jobson, Jeremy Cheong, Kelvin Gotama, Luciana Maffei, Mai Hase, Alhafidz Hamdan, Ren Ding, Tuomo Polivkoski, Karen Horsburgh, Raj N. Kalaria   +10 more
doaj   +1 more source

The Import of Vitalism

Science, 1911
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openaire   +3 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Vitality of Leaves [PDF]

Nature, 1908
I HAVE in my possession a sprig of Bryophyllum calycinum which was cut off a plant in Jamaica six months ago, at the beginning of June. It has still attached to it three leaves, which are quite green, and at the edges of these there are minute new shoots projecting from the crenations.
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Community Nurses’ Perceptions of Their Role as Health Promoters in Collective Prevention: A Qualitative Study in Dutch Community Nursing Care

Journal of Primary Care & Community Health
Introduction: Addressing the demands of an ageing population requires a shift from individualised to collective prevention. Collective prevention adopts a socio-ecological approach, mobilising communities to improve population health. This study explores
Sara Francina Mirjam de Leede-Brunsveld, Geertuida Johanna (Truus) Teunissen, Jolanda Lindenberg, David van Bodegom, Johanna Adriana Henrica (Anneke) van Vught   +4 more
doaj   +1 more source

Comprehensive measurement of stroke gait characteristics with a single accelerometer in the laboratory and community: a feasibility, validity and reliability study

Journal of NeuroEngineering and Rehabilitation, 2017
Background Application of objective measurement of stroke gait with accelerometer-based wearable technology and associated algorithms is increasing, despite reports questioning the accuracy of this technique in quantifying specific stroke-related gait ...
Sarah A. Moore, Aodhan Hickey, Sue Lord, Silvia Del Din, Alan Godfrey, Lynn Rochester   +5 more
doaj   +1 more source

HB 3210 Task Force on Heritage Vitality executive summary report

, 2012
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF cover (viewed on Nov. 1, 2013)"September 2012.

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