Results 151 to 160 of about 119,254,893 (314)

An Injectable and Self‐Reinforced Piezoelectric Hydrogel for Irregular Bone Defects Regeneration: Dynamic Epigenetic Regulation Approach

open access: yesAdvanced Science, EarlyView.
An injectable and self‐reinforcing RSF‐based piezoelectric hydrogel conforms to irregular bone defects and progressively strengthens in situ, overcoming the trade‐off between injectability and mechanical stability. Mechanical loading generates bioelectrical cues that promote P300‐mediated H3K9 acetylation and upregulate PTH1R expression, thereby ...
Yu‐Kai Huang   +15 more
wiley   +1 more source

Importance of Application-Specific Testing for Vitamin A in Food Fortification

open access: yesCurrent Developments in Nutrition
Haisong Yang   +5 more
doaj   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

open access: yesAdvanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha   +5 more
wiley   +1 more source

Nutrition, Education and Development: The Case of Vitamin D Milk [PDF]

open access: yes
Micronutrient deficiencies that reduce the health of children risk impeding human capital investments critical for economic development. While the developed world has largely eliminated the most pernicious of these deficiencies, they remain widespread in
Schwab, Benjamin
core  

Bioelectrochemically Powered Out‐of‐Equilibrium Hydrogels Enable Feedback‐Regulated Functions

open access: yesAdvanced Science, EarlyView.
A bioelectrochemically powered hydrogel operates far from equilibrium via an antagonistic redox cycle that regulates disulfide exchange within a polyrotaxane network. Coupling electrochemical mediator cycling with enzymatic feedback enables dynamic control of hydrogel mechanics and transport properties, driving glucose‐responsive insulin release with ...
Roberto Baretta, Marco Frasconi
wiley   +1 more source

Supramolecular Chiral Assemblies from Benzoselenadiazole‐Alanine‐Acylhydrazone Conjugates Enable Cardioprotection

open access: yesAdvanced Science, EarlyView.
The C3‐symmetric conjugate TASe, which integrates benzoselenadiazole, alanine, and acylhydrazone modules, self‐assembles into a chalcogen‐/hydrogen‐bonded porous framework in the solid state and uniform chiral nanospheres in aqueous media. These assemblies protect cardiomyocytes from doxorubicin‐induced oxidative injury by scavenging intracellular ...
Jinkui Teng   +11 more
wiley   +1 more source

Tolerância à aplicação de megadoses de vitamina A associada à vacinação em crianças no Nordeste do Brasil

open access: yesCadernos de Saúde Pública
Um estudo de seguimento foi desenvolvido em duas localidades do semi-árido do estado da Bahia, Nordeste do Brasil, com o objetivo de identificar a ocorrência e a natureza de possíveis efeitos adversos agudos em conseqüência da suplementação com megadoses
Ana Marlúcia Oliveira Assis   +4 more
doaj  

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

open access: yesAdvanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan   +5 more
wiley   +1 more source

Advancing Clinical Research

open access: yes
Advanced Science, EarlyView.
wiley   +1 more source

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