Results 61 to 70 of about 779,253 (317)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Vitamin D Status and its Association with Morbidity Including Wasting and Opportunistic Illnesses in HIV-Infected Women in Tanzania [PDF]

, 2011
Vitamin D has a potential role in preventing HIV-related complications, based on its extensive involvement in immune and metabolic function, including preventing osteoporosis and premature cardiovascular disease.
Mugusi, Ferdinand M, Fawzi, Wafaie W., Mehta, Saurabh, Hertzmark, E., Saurabh Mehta, Mugusi, Ferdinand M., Spiegelman, D., Gernard I. Msamanga, Giovannucci, Edward L., Giovannucci, Edward L, Edward L. Giovannucci, Villamor, Eduardo, Spiegelman, Donna, Mehta, S., Fawzi, W.W., Hertzmark, Ellen, Julia L. Finkelstein, Ferdinand M. Mugusi, Ellen Hertzmark, Villamor, E., Finkelstein, Julia L., Finkelstein, Julia L, Eduardo Villamor, Msamanga, G.I., Msamanga, Gernard I., Finkelstein, J.L., Msamanga, Gernard I, Donna Spiegelman, Fawzi, Wafaie W, Wafaie W. Fawzi, Giovannucci, E.L., Mugusi, F.M.   +31 more
core   +1 more source

Pengaruh Fortifikasi Vitamin A dan Zat Besi Terenkapsulasi pada Tepung Ubi Kayu dan Aplikasinya pada Pembuatan Flakes

Agritech, 2019
Fortification is one of the promising techniques for decreasing micronutrient deficiency problem, particularly in vitamin A and iron cases. This research aimed to investigate the effect of encapsulated vitamin A and iron fortification on cassava flour ...
Windi Asterini, Sugiyono Sugiyono, Hoerudin Hoerudin, Endang Prangdimurti   +3 more
doaj   +1 more source

Vitamin D: The "sunshine" vitamin.

Journal of pharmacology & pharmacotherapeutics, 2012
Vitamin D insufficiency affects almost 50% of the population worldwide. An estimated 1 billion people worldwide, across all ethnicities and age groups, have a vitamin D deficiency (VDD). This pandemic of hypovitaminosis D can mainly be attributed to lifestyle (for example, reduced outdoor activities) and environmental (for example, air pollution ...
Nair, Rathish, Maseeh, Arun
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Vitamin C inhibits endothelial cell apoptosis in congestive heart failure [PDF]

, 2001
Background - Proinflammatory cytokines like tumor necrosis factor- and oxidative stress induce apoptotic cell death in endothelial cells (ECs). Systemic inflammation and increased oxidative stress in congestive heart failure (CHF) coincide with enhanced ...
Dimmeler, S, Rossig, L, Aicher, A, Haase, A, Freyssinet, JM, Tedgui, A, Hugel, B, Zeiher, AM, Hoffmann, J, Mallat, Z   +9 more
core   +1 more source

VITAMINES AND NUTRITION [PDF]

Science, 1918
n ...
openaire   +4 more sources

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Az A-vitamin származékok hatása az immunrendszerre [PDF]

, 2014
Az A-vitamin olyan fontos tápanyag, amely szerepet kap a látásban, az egészséges magzat fejlődésében, valamint a megfelelő immunműködésben. Ugyanakkor, mint minden tápanyag bevitelére, az A-vitamin mennyiségre is figyelni kell.
Szücs, Gabriella
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source