Angewandte Chemie, EarlyView.We introduce a novel chemical derivatisation strategy for the UV‐activated detection of elusive metabolites. Incorporation of a tocopherol‐active chromophore allows for the detection of tagged analytes as photoionised radical cations, selectively induced by a 266 nm laser.
Sofia R. McGowan +5 more
wiley +2 more sources
Annals of Neurology, EarlyView.Objective Both high and declining blood pressure (BP) are associated with risk of cognitive decline in older adults, and women have higher rates of hypertension and faster cognitive decline in late‐life. In old age, the relationship between changes in BP and changes in cognition is complex, and although sex differences in cognitive function and decline
Nicholas W. Baumgartner +4 more
wiley +1 more source
Evaluating the efficacy and tolerability of the oral combination of alpha lipoic acid and vitamin B complex preparation in carpal tunnel syndrome: a single center, randomized, double-blind, placebo-controlled trial. [PDF]
BMC NeurolZainal NA +5 more
europepmc +1 more source
Flavin Catalysts in Organic Synthesis
Angewandte Chemie, EarlyView.Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley +2 more sources
Annals of Neurology, EarlyView.Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera +16 more
wiley +1 more source
The effects of vitamin B and D supplementations on autonomic functions and quality of life in children after vasovagal syncope. [PDF]
Front PediatrKovalchuk T, Boyarchuk O, Balatska N.
europepmc +1 more source
Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, EarlyView.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources
<i>Helicobacter pylori</i> Infection and Anemia: The Potential Role of Vitamin C and Vitamin B<sub>12</sub>. [PDF]
MoleculesWróblewska J +6 more
europepmc +1 more source
Cobalt‐Catalyzed Radical Ligand Transfer (RLT) Enables Remote‐Markovnikov Hydroamination of Alkenes
Angewandte Chemie, EarlyView.A cobalt‐catalyzed remote‐Markovnikov 1,3‐hydroamination of allyl carboxylates proceeds through MHAT, 1,2‐radical acyloxy migration (1,2‐RAM), and radical ligand transfer (RLT) from a Co‐N intermediate, providing protected amino alcohols. ABSTRACT Amino alcohols are prevalent in pharmaceuticals, agrochemicals, and functional materials, yet ...
Arman Khosravi +7 more
wiley +2 more sources
Comparison of vitamin B levels in febrile children with and without febrile seizures: A prospective single-center study. [PDF]
Medicine (Baltimore)Huang Y, Wen X, Guo H, Cao J.
europepmc +1 more source